Gene description for SYN2
Gene name synapsin II
Gene symbol SYN2
Other names/aliases SYNII
Species Homo sapiens
 Database cross references - SYN2
ExoCarta ExoCarta_6854
Vesiclepedia VP_6854
Entrez Gene 6854
HGNC 11495
MIM 600755
UniProt Q92777  
 SYN2 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SYN2
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 TAS
    identical protein binding GO:0042802 IEA
Biological Process
    chemical synaptic transmission GO:0007268 TAS
    neurotransmitter secretion GO:0007269 ISS
    calcium-ion regulated exocytosis GO:0017156 IEA
    synapse organization GO:0050808 IBA
    synaptic vesicle clustering GO:0097091 IBA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    postsynaptic density GO:0014069 IEA
    synaptic vesicle membrane GO:0030672 IBA
    synaptic vesicle membrane GO:0030672 ISS
    SNARE complex GO:0031201 IEA
    synapse GO:0045202 ISS
    Schaffer collateral - CA1 synapse GO:0098685 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified SYN2 in sEVs
1
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SYN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GPM6A 2823
Affinity Capture-MS Homo sapiens
2 HAX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 DNAAF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SYN2 6854
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 PSMC3 5702
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 SYN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
7 TP53 7157
Negative Genetic Homo sapiens
8 PRNP 5621
Affinity Capture-MS Homo sapiens
9 NOS1AP  
Reconstituted Complex Homo sapiens
10 YWHAB 7529
Affinity Capture-MS Homo sapiens
11 PDCD6IP 10015
Affinity Capture-MS Homo sapiens
12 YWHAE 7531
Two-hybrid Homo sapiens
13 IQCB1  
Affinity Capture-MS Homo sapiens
14 CHRM4  
Two-hybrid Homo sapiens
15 YWHAZ 7534
Two-hybrid Homo sapiens
16 CAPZB 832
Affinity Capture-MS Homo sapiens
17 DGUOK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 ARMC1 55156
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 POLL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 GNB2L1 10399
Affinity Capture-Western Homo sapiens
21 SYN1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
22 DUSP2  
Affinity Capture-MS Homo sapiens
23 YWHAG 7532
Affinity Capture-MS Homo sapiens
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