Gene description for TLR1
Gene name toll-like receptor 1
Gene symbol TLR1
Other names/aliases CD281
TIL
TIL. LPRS5
rsc786
Species Homo sapiens
 Database cross references - TLR1
ExoCarta ExoCarta_7096
Vesiclepedia VP_7096
Entrez Gene 7096
HGNC 11847
MIM 601194
UniProt Q15399  
 TLR1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TLR1
Molecular Function
    transmembrane signaling receptor activity GO:0004888 NAS
    protein binding GO:0005515 IPI
    Toll-like receptor 2 binding GO:0035663 IBA
    Toll-like receptor 2 binding GO:0035663 IPI
    signaling receptor activity GO:0038023 IBA
    identical protein binding GO:0042802 IPI
    NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 IEA
    lipopeptide binding GO:0071723 IBA
Biological Process
    microglial cell activation GO:0001774 IEA
    toll-like receptor signaling pathway GO:0002224 IBA
    toll-like receptor signaling pathway GO:0002224 IDA
    toll-like receptor signaling pathway GO:0002224 ISS
    inflammatory response GO:0006954 IBA
    immune response GO:0006955 TAS
    signal transduction GO:0007165 TAS
    positive regulation of interleukin-6 production GO:0032755 ISS
    positive regulation of interleukin-8 production GO:0032757 IGI
    positive regulation of tumor necrosis factor production GO:0032760 ISS
    positive regulation of toll-like receptor 2 signaling pathway GO:0034137 IGI
    macrophage activation GO:0042116 NAS
    detection of triacyl bacterial lipopeptide GO:0042495 IDA
    innate immune response GO:0045087 NAS
    cellular response to triacyl bacterial lipopeptide GO:0071727 IBA
    cellular response to triacyl bacterial lipopeptide GO:0071727 IDA
    cellular response to triacyl bacterial lipopeptide GO:0071727 IDA
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 NAS
    phagocytic vesicle membrane GO:0030670 IEA
    Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 IBA
    Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 IDA
    Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 IPI
    receptor complex GO:0043235 IPI
    membrane raft GO:0045121 IDA
 Experiment description of studies that identified TLR1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TLR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TLR2 7097
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 COLEC12 81035
Affinity Capture-MS Homo sapiens
3 TLR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 MAVS 57506
Affinity Capture-MS Homo sapiens
5 STK11IP 114790
Affinity Capture-MS Homo sapiens
6 PLXNB2 23654
Affinity Capture-MS Homo sapiens
7 ALDH16A1 126133
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TBC1D24 57465
Affinity Capture-MS Homo sapiens
9 TLR4  
Affinity Capture-Western Homo sapiens
10 CNPY3 10695
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TMX1 81542
Affinity Capture-MS Homo sapiens
12 LRP6 4040
Affinity Capture-MS Homo sapiens
13 MUCL1  
Affinity Capture-MS Homo sapiens
14 TMEM214 54867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 DERA 51071
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here