Gene description for Cyfip2
Gene name cytoplasmic FMR1 interacting protein 2
Gene symbol Cyfip2
Other names/aliases 1500004I01Rik
6430511D02Rik
AA930218
AU022376
Pir121
mKIAA1168
Species Mus musculus
 Database cross references - Cyfip2
ExoCarta ExoCarta_76884
Vesiclepedia VP_76884
Entrez Gene 76884
UniProt Q5SQX6  
 Cyfip2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cyfip2
Molecular Function
    RNA 7-methylguanosine cap binding GO:0000340 IBA
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IEA
Biological Process
    cell morphogenesis GO:0000902 IBA
    apoptotic process GO:0006915 IBA
    apoptotic process GO:0006915 ISO
    apoptotic process GO:0006915 ISS
    axon guidance GO:0007411 IBA
    cell projection assembly GO:0030031 IBA
    regulation of actin filament polymerization GO:0030833 IEA
    neuron projection development GO:0031175 IMP
    positive regulation of proteolysis GO:0045862 IEA
    positive regulation of proteolysis GO:0045862 ISO
    positive regulation of neurotrophin TRK receptor signaling pathway GO:0051388 IMP
    activation of cysteine-type endopeptidase activity GO:0097202 ISO
    dendrite extension GO:0097484 IMP
    cell-cell adhesion GO:0098609 ISO
    cell-cell adhesion GO:0098609 ISS
    regulation of postsynapse assembly GO:0150052 IEA
    regulation of postsynapse assembly GO:0150052 ISO
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    SCAR complex GO:0031209 IDA
    SCAR complex GO:0031209 ISO
    neuron projection GO:0043005 IBA
    neuron projection GO:0043005 IEA
    synapse GO:0045202 EXP
    synapse GO:0045202 IBA
    synapse GO:0045202 IDA
    synapse GO:0045202 IEP
    synapse GO:0045202 IMP
    synapse GO:0045202 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    perinuclear region of cytoplasm GO:0048471 ISS
 Experiment description of studies that identified Cyfip2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cyfip2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Wasf1  
Affinity Capture-MS Mus musculus
Co-fractionation Mus musculus
2 Camk2a  
Affinity Capture-MS Mus musculus
3 Tnik  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
4 Cntnap1  
Affinity Capture-MS Mus musculus
5 Mycbp2 105689
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
6 Caskin1  
Affinity Capture-MS Mus musculus
7 Pacsin1  
Co-fractionation Mus musculus
8 Stau1  
Co-fractionation Mus musculus
9 Ctnnb1 12387
Affinity Capture-MS Mus musculus
10 Myo5a 17918
Affinity Capture-MS Mus musculus
11 Etl4  
Affinity Capture-MS Mus musculus
12 Nhsl2  
Affinity Capture-MS Mus musculus
13 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
14 Dnm1 13429
Affinity Capture-MS Mus musculus
15 Syngap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
16 Mapt  
Affinity Capture-MS Mus musculus
17 Fmr1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
18 Kctd13  
Affinity Capture-MS Mus musculus
19 Dlg4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
20 Nlgn3  
Affinity Capture-MS Mus musculus
21 Shank1 243961
Affinity Capture-MS Mus musculus
22 Shank3  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
23 Pex5l  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
24 Cdh10 320873
Affinity Capture-MS Mus musculus
25 Kcnma1  
Affinity Capture-MS Mus musculus
26 Wasf2 242687
Co-fractionation Mus musculus
27 Sptbn1 20742
Affinity Capture-MS Mus musculus
28 Nckap1 50884
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
29 Map3k5  
Affinity Capture-MS Mus musculus
30 Pacsin3 80708
Co-fractionation Mus musculus
31 Cyfip1 20430
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
32 Srgap3  
Affinity Capture-MS Mus musculus
33 Abi1 11308
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
34 Agap2  
Affinity Capture-MS Mus musculus
35 Fyco1  
Affinity Capture-MS Mus musculus
36 Ina  
Affinity Capture-MS Mus musculus
37 Abi2  
Affinity Capture-MS Mus musculus
38 Cttnbp2  
Affinity Capture-MS Mus musculus
39 Tsc1  
Affinity Capture-MS Mus musculus
40 Ap2a1 11771
Affinity Capture-MS Mus musculus
41 Sptbn2  
Affinity Capture-MS Mus musculus
42 Cdh2 12558
Affinity Capture-MS Mus musculus
43 Appl1  
Affinity Capture-MS Mus musculus
44 Camk2b 12323
Affinity Capture-MS Mus musculus
45 Atg16l1  
Affinity Capture-MS Mus musculus
46 Sptan1 20740
Affinity Capture-MS Mus musculus
47 Tpp2 22019
Affinity Capture-MS Mus musculus
48 Nek9  
Affinity Capture-MS Mus musculus
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