Gene description for KCTD15
Gene name potassium channel tetramerization domain containing 15
Gene symbol KCTD15
Other names/aliases -
Species Homo sapiens
 Database cross references - KCTD15
ExoCarta ExoCarta_79047
Vesiclepedia VP_79047
Entrez Gene 79047
HGNC 23297
MIM 615240
UniProt Q96SI1  
 KCTD15 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for KCTD15
Molecular Function
    transcription corepressor activity GO:0003714 IBA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    negative regulation of DNA-templated transcription GO:0045892 IBA
    protein homooligomerization GO:0051260 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified KCTD15 in sEVs
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KCTD15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATXN1 6310
Two-hybrid Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 TERF2  
Affinity Capture-MS Homo sapiens
4 CA10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 FEV  
Proximity Label-MS Homo sapiens
6 TP53 7157
Affinity Capture-MS Homo sapiens
7 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 RUVBL2 10856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 NOTCH2NL 388677
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
10 TFAP2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 NOXA1  
Two-hybrid Homo sapiens
12 TMEM184A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 NBPF19  
Two-hybrid Homo sapiens
14 SP7  
Proximity Label-MS Homo sapiens
15 TRIM55  
Two-hybrid Homo sapiens
16 SOX2  
Affinity Capture-MS Homo sapiens
17 TERF1 7013
Affinity Capture-MS Homo sapiens
18 NSMF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 PRPF39 55015
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 WDYHV1  
Two-hybrid Homo sapiens
21 CYSRT1 375791
Two-hybrid Homo sapiens
22 S100P 6286
Affinity Capture-MS Homo sapiens
23 REN  
Two-hybrid Homo sapiens
24 WIPI1 55062
Two-hybrid Homo sapiens
25 HSPA1A 3303
Affinity Capture-MS Homo sapiens
26 KCTD19  
Affinity Capture-MS Homo sapiens
27 KCTD1 284252
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
28 KCTD21 283219
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
29 KCTD15 79047
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
30 KCTD3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 MBD3L2  
Affinity Capture-MS Homo sapiens
32 TRIM63  
Two-hybrid Homo sapiens
View the network image/svg+xml



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