Gene description for DCAKD
Gene name dephospho-CoA kinase domain containing
Gene symbol DCAKD
Other names/aliases -
Species Homo sapiens
 Database cross references - DCAKD
ExoCarta ExoCarta_79877
Vesiclepedia VP_79877
Entrez Gene 79877
HGNC 26238
UniProt Q8WVC6  
 DCAKD identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for DCAKD
Molecular Function
    dephospho-CoA kinase activity GO:0004140 EXP
    dephospho-CoA kinase activity GO:0004140 IBA
    ATP binding GO:0005524 IEA
Biological Process
    coenzyme A biosynthetic process GO:0015937 IBA
    coenzyme A biosynthetic process GO:0015937 TAS
Subcellular Localization
    mitochondrial outer membrane GO:0005741 TAS
    membrane GO:0016020 HDA
 Experiment description of studies that identified DCAKD in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DCAKD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 OR2M7  
Affinity Capture-MS Homo sapiens
2 LPPR4  
Affinity Capture-MS Homo sapiens
3 FTL 2512
Affinity Capture-MS Homo sapiens
4 DUSP22  
Affinity Capture-MS Homo sapiens
5 CRLF2 64109
Affinity Capture-MS Homo sapiens
6 CYP26B1  
Affinity Capture-MS Homo sapiens
7 TMEM106A  
Affinity Capture-MS Homo sapiens
8 SLC30A2  
Affinity Capture-MS Homo sapiens
9 MCM2 4171
Affinity Capture-MS Homo sapiens
10 TTYH1  
Affinity Capture-MS Homo sapiens
11 CANX 821
Affinity Capture-MS Homo sapiens
12 HLA-G 3135
Affinity Capture-MS Homo sapiens
13 SIDT2 51092
Affinity Capture-MS Homo sapiens
14 IMPDH1 3614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SRPRB 58477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PEX19 5824
Affinity Capture-MS Homo sapiens
17 ZDHHC12  
Affinity Capture-MS Homo sapiens
18 KCNG4  
Affinity Capture-MS Homo sapiens
19 SLC26A1  
Affinity Capture-MS Homo sapiens
20 MCOLN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SHISA3  
Affinity Capture-MS Homo sapiens
22 IL22RA1 58985
Affinity Capture-MS Homo sapiens
23 CHRNA7  
Affinity Capture-MS Homo sapiens
24 TMEM9B 56674
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 UBC 7316
Affinity Capture-MS Homo sapiens
26 NSDHL 50814
Affinity Capture-MS Homo sapiens
27 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
28 TMX1 81542
Affinity Capture-MS Homo sapiens
29 FCER1A  
Affinity Capture-MS Homo sapiens
30 GPR114  
Affinity Capture-MS Homo sapiens
31 APBB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TMEM169  
Affinity Capture-MS Homo sapiens
33 CTXN1  
Affinity Capture-MS Homo sapiens
34 HCCS 3052
Affinity Capture-MS Homo sapiens
35 IL4R  
Affinity Capture-MS Homo sapiens
36 PTPN5  
Affinity Capture-MS Homo sapiens
37 Samm50  
Affinity Capture-MS Mus musculus
38 TMEM204  
Affinity Capture-MS Homo sapiens
39 TM2D3  
Affinity Capture-MS Homo sapiens
40 DLK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 PCDH10 57575
Affinity Capture-MS Homo sapiens
42 INSRR 3645
Affinity Capture-MS Homo sapiens
43 OR6T1  
Affinity Capture-MS Homo sapiens
44 COQ9  
Affinity Capture-MS Homo sapiens
45 FAM57A  
Affinity Capture-MS Homo sapiens
46 OR1M1  
Affinity Capture-MS Homo sapiens
47 TMPRSS3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 RDH11 51109
Affinity Capture-MS Homo sapiens
49 FAM189A2  
Affinity Capture-MS Homo sapiens
50 EVA1B 55194
Affinity Capture-MS Homo sapiens
51 KCNA2  
Affinity Capture-MS Homo sapiens
52 ENTPD2 954
Affinity Capture-MS Homo sapiens
53 COMT 1312
Affinity Capture-MS Homo sapiens
54 PIGH  
Affinity Capture-MS Homo sapiens
55 CCT8L2  
Affinity Capture-MS Homo sapiens
56 RPA3 6119
Proximity Label-MS Homo sapiens
57 ESYT1 23344
Affinity Capture-MS Homo sapiens
58 C3orf52  
Affinity Capture-MS Homo sapiens
59 FOXS1  
Affinity Capture-MS Homo sapiens
60 METTL21B  
Affinity Capture-MS Homo sapiens
61 PIPSL 266971
Affinity Capture-MS Homo sapiens
62 UST  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 CCDC47 57003
Affinity Capture-MS Homo sapiens
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