Gene description for IL22RA1
Gene name interleukin 22 receptor, alpha 1
Gene symbol IL22RA1
Other names/aliases CRF2-9
IL22R
IL22R1
Species Homo sapiens
 Database cross references - IL22RA1
ExoCarta ExoCarta_58985
Vesiclepedia VP_58985
Entrez Gene 58985
HGNC 13700
MIM 605457
UniProt Q8N6P7  
 IL22RA1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IL22RA1
Molecular Function
    cytokine receptor activity GO:0004896 IBA
    interferon receptor activity GO:0004904 TAS
    protein binding GO:0005515 IPI
    interleukin-20 binding GO:0042015 IEA
    interleukin-22 receptor activity GO:0042018 ISS
Biological Process
    cytokine-mediated signaling pathway GO:0019221 IBA
    negative regulation of inflammatory response GO:0050728 ISS
    defense response to Gram-negative bacterium GO:0050829 IEA
    interleukin-22-mediated signaling pathway GO:0140865 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified IL22RA1 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IL22RA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UPK3BL 100134938
Affinity Capture-MS Homo sapiens
2 IL22  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 DHRS7 51635
Affinity Capture-MS Homo sapiens
4 PIGA  
Affinity Capture-MS Homo sapiens
5 ATP13A2  
Affinity Capture-MS Homo sapiens
6 CTDNEP1 23399
Affinity Capture-MS Homo sapiens
7 APC  
Negative Genetic Homo sapiens
8 TYW1  
Affinity Capture-MS Homo sapiens
9 HRAS 3265
Negative Genetic Homo sapiens
10 EPHX1 2052
Affinity Capture-MS Homo sapiens
11 NFRKB  
Affinity Capture-MS Homo sapiens
12 GHDC  
Affinity Capture-MS Homo sapiens
13 VHL  
Negative Genetic Homo sapiens
14 FBXW12  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
15 DCAKD 79877
Affinity Capture-MS Homo sapiens
16 PDZD8 118987
Affinity Capture-MS Homo sapiens
17 CYP51A1 1595
Affinity Capture-MS Homo sapiens
18 SLITRK5  
Affinity Capture-MS Homo sapiens
19 RETSAT 54884
Affinity Capture-MS Homo sapiens
20 FAM69A 388650
Affinity Capture-MS Homo sapiens
21 CYB5R1 51706
Affinity Capture-MS Homo sapiens
22 SMPD2 6610
Affinity Capture-MS Homo sapiens
23 FGFR4 2264
Negative Genetic Homo sapiens
24 DHRS3 9249
Affinity Capture-MS Homo sapiens
25 CCPG1 9236
Affinity Capture-MS Homo sapiens
26 STAT3 6774
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
27 ATP2A3 489
Affinity Capture-MS Homo sapiens
28 TMX2 51075
Affinity Capture-MS Homo sapiens
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