Gene description for CAB39L
Gene name calcium binding protein 39-like
Gene symbol CAB39L
Other names/aliases MO25-BETA
MO2L
bA103J18.3
Species Homo sapiens
 Database cross references - CAB39L
ExoCarta ExoCarta_81617
Vesiclepedia VP_81617
Entrez Gene 81617
HGNC 20290
MIM 612175
UniProt Q9H9S4  
 CAB39L identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
Urine 19056867    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for CAB39L
Molecular Function
    protein binding GO:0005515 IPI
    protein serine/threonine kinase activator activity GO:0043539 IBA
Biological Process
    intracellular signal transduction GO:0035556 IBA
Subcellular Localization
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 TAS
    serine/threonine protein kinase complex GO:1902554 ISS
 Experiment description of studies that identified CAB39L in sEVs
1
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
3
Experiment ID 196
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 197
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CAB39L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACOT7 11332
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 EPB41L1 2036
Affinity Capture-MS Homo sapiens
3 ELMO3 79767
Affinity Capture-MS Homo sapiens
4 DCXR 51181
Co-fractionation Homo sapiens
5 PLCB3 5331
Affinity Capture-MS Homo sapiens
6 BCKDK 10295
Affinity Capture-MS Homo sapiens
7 GBP1 2633
Affinity Capture-MS Homo sapiens
8 FAS 355
Affinity Capture-MS Homo sapiens
9 CHMP1A 5119
Affinity Capture-MS Homo sapiens
10 MX1 4599
Two-hybrid Homo sapiens
11 MLH1 4292
Two-hybrid Homo sapiens
12 STRADA 92335
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 BTF3L4 91408
Affinity Capture-MS Homo sapiens
14 CAB39 51719
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PUS7 54517
Affinity Capture-MS Homo sapiens
16 CCNL2 81669
Affinity Capture-MS Homo sapiens
17 RAP1B 5908
Affinity Capture-MS Homo sapiens
18 FYN 2534
Affinity Capture-MS Homo sapiens
19 BCL7B  
Affinity Capture-MS Homo sapiens
20 LIN7C 55327
Affinity Capture-MS Homo sapiens
21 SCML2  
Two-hybrid Homo sapiens
22 STK11 6794
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 MAGOHB 55110
Affinity Capture-MS Homo sapiens
24 PAF1 54623
Affinity Capture-MS Homo sapiens
25 METTL15  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CAB39L is involved
PathwayEvidenceSource
Energy dependent regulation of mTOR by LKB1-AMPK TAS Reactome
MTOR signalling TAS Reactome
Signal Transduction TAS Reactome





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