Gene description for EMC6
Gene name ER membrane protein complex subunit 6
Gene symbol EMC6
Other names/aliases TMEM93
Species Homo sapiens
 Database cross references - EMC6
ExoCarta ExoCarta_83460
Vesiclepedia VP_83460
Entrez Gene 83460
HGNC 28430
UniProt Q9BV81  
 EMC6 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for EMC6
Molecular Function
    protein binding GO:0005515 IPI
    membrane insertase activity GO:0032977 IMP
Biological Process
    autophagosome assembly GO:0000045 IBA
    autophagosome assembly GO:0000045 IMP
    protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO:0045050 IDA
    protein insertion into ER membrane by stop-transfer membrane-anchor sequence GO:0045050 IMP
    tail-anchored membrane protein insertion into ER membrane GO:0071816 IDA
    tail-anchored membrane protein insertion into ER membrane GO:0071816 IMP
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 NAS
    membrane GO:0016020 IDA
    EMC complex GO:0072546 IBA
    EMC complex GO:0072546 IDA
    EMC complex GO:0072546 IPI
    EMC complex GO:0072546 ISS
    omegasome membrane GO:1903349 IDA
 Experiment description of studies that identified EMC6 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for EMC6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 REEP5 7905
Affinity Capture-MS Homo sapiens
3 C4orf32  
Affinity Capture-MS Homo sapiens
4 SLC10A6  
Two-hybrid Homo sapiens
5 EMC3 55831
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 EMC8 10328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 EMC1 23065
Affinity Capture-MS Homo sapiens
8 EMC9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 UNK  
Affinity Capture-RNA Homo sapiens
10 EMC7 56851
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 EMC10 284361
Affinity Capture-MS Homo sapiens
12 ERGIC3 51614
Two-hybrid Homo sapiens
13 TMEM14B  
Two-hybrid Homo sapiens
14 TSPAN15 23555
Affinity Capture-MS Homo sapiens
15 EGFR 1956
Negative Genetic Homo sapiens
16 DNAJC25 548645
Proximity Label-MS Homo sapiens
17 EBP  
Two-hybrid Homo sapiens
18 CD79A  
Two-hybrid Homo sapiens
19 LPAR1 1902
Affinity Capture-MS Homo sapiens
20 MMGT1 93380
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
21 FAM209A 200232
Two-hybrid Homo sapiens
22 GOLPH3L 55204
Affinity Capture-MS Homo sapiens
23 SLC39A2  
Two-hybrid Homo sapiens
24 NADSYN1 55191
Affinity Capture-MS Homo sapiens
25 SREBF2 6721
Negative Genetic Homo sapiens
26 LDLR 3949
Negative Genetic Homo sapiens
27 EMC2 9694
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 EMC4 51234
Affinity Capture-MS Homo sapiens
29 NCLN 56926
Affinity Capture-MS Homo sapiens
30 TMEM259 91304
Affinity Capture-MS Homo sapiens
31 MMD  
Two-hybrid Homo sapiens
32 PDZK1IP1 10158
Two-hybrid Homo sapiens
33 MUC1 4582
Two-hybrid Homo sapiens
34 CREB3  
Two-hybrid Homo sapiens
35 TMEM56  
Two-hybrid Homo sapiens
36 TMEM237 65062
Two-hybrid Homo sapiens
37 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 OSBPL8 114882
Affinity Capture-MS Homo sapiens
39 CCDC47 57003
Affinity Capture-MS Homo sapiens
40 PLAC9 219348
Affinity Capture-MS Homo sapiens
41 REEP6  
Affinity Capture-MS Homo sapiens
42 HIATL1 84641
Two-hybrid Homo sapiens
43 SLC7A1 6541
Two-hybrid Homo sapiens
44 AQP9  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which EMC6 is involved
No pathways found





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