Gene description for Srrt
Gene name serrate RNA effector molecule homolog (Arabidopsis)
Gene symbol Srrt
Other names/aliases 2810019G02Rik
ASR2A
ASR2B
ASR2C
ASR2D
Ars2
Asr2
Species Mus musculus
 Database cross references - Srrt
ExoCarta ExoCarta_83701
Vesiclepedia VP_83701
Entrez Gene 83701
UniProt Q99MR6  
 Srrt identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Srrt
Molecular Function
    DNA binding GO:0003677 IDA
    protein binding GO:0005515 IPI
    protein-macromolecule adaptor activity GO:0030674 IEA
    protein-macromolecule adaptor activity GO:0030674 ISO
    mRNA cap binding complex binding GO:0140262 IEA
    mRNA cap binding complex binding GO:0140262 ISO
Biological Process
    regulation of DNA-templated transcription GO:0006355 IDA
    mRNA processing GO:0006397 IEA
    primary miRNA processing GO:0031053 IBA
    primary miRNA processing GO:0031053 IMP
    primary miRNA processing GO:0031053 ISO
    positive regulation of neurogenesis GO:0050769 IMP
    neuronal stem cell population maintenance GO:0097150 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IDA
    nuclear body GO:0016604 IBA
    protein-containing complex GO:0032991 ISO
    ribonucleoprotein complex GO:1990904 IEA
    ribonucleoprotein complex GO:1990904 ISO
 Experiment description of studies that identified Srrt in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Srrt
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Atxn1  
Affinity Capture-MS Mus musculus
3 Tardbp 230908
Co-fractionation Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 MKRN1 23608
Affinity Capture-MS Homo sapiens
6 Acly 104112
Co-fractionation Mus musculus
7 Hspa8 15481
Co-fractionation Mus musculus
8 Cops8 108679
Co-fractionation Mus musculus
View the network image/svg+xml



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