Gene description for Cops8
Gene name COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana)
Gene symbol Cops8
Other names/aliases 9430009J09Rik
AA408242
Csn8
Sgn8
Species Mus musculus
 Database cross references - Cops8
ExoCarta ExoCarta_108679
Vesiclepedia VP_108679
Entrez Gene 108679
UniProt Q8VBV7  
 Cops8 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Cops8
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    protein deneddylation GO:0000338 IEA
    protein deneddylation GO:0000338 ISO
    protein phosphorylation GO:0006468 ISO
    activation of NF-kappaB-inducing kinase activity GO:0007250 ISO
    negative regulation of cell population proliferation GO:0008285 IEA
    negative regulation of cell population proliferation GO:0008285 ISO
    COP9 signalosome assembly GO:0010387 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    COP9 signalosome GO:0008180 IBA
    COP9 signalosome GO:0008180 IDA
    COP9 signalosome GO:0008180 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Cops8 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cops8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Skp1a 21402
Co-fractionation Mus musculus
2 Cops5 26754
Affinity Capture-Western Mus musculus
3 Chaf1a  
Affinity Capture-MS Mus musculus
4 CUL1 8454
Affinity Capture-MS Homo sapiens
5 Eed  
Affinity Capture-MS Mus musculus
6 GPS1 2873
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
7 Socs3  
Affinity Capture-Western Mus musculus
8 Cops2 12848
Affinity Capture-Western Mus musculus
9 Cul4b  
Co-fractionation Mus musculus
10 Gsk3b  
Biochemical Activity Mus musculus
11 Srrt 83701
Co-fractionation Mus musculus
12 Gps1 209318
Co-fractionation Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
13 Fancd2  
Affinity Capture-MS Mus musculus
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