Gene description for BCAR3
Gene name breast cancer anti-estrogen resistance 3
Gene symbol BCAR3
Other names/aliases NSP2
SH2D3B
Species Homo sapiens
 Database cross references - BCAR3
ExoCarta ExoCarta_8412
Vesiclepedia VP_8412
Entrez Gene 8412
HGNC 973
MIM 604704
UniProt O75815  
 BCAR3 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for BCAR3
Molecular Function
    phosphotyrosine residue binding GO:0001784 IMP
    guanyl-nucleotide exchange factor activity GO:0005085 IEA
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 IPI
Biological Process
    lens morphogenesis in camera-type eye GO:0002089 IEA
    signal transduction GO:0007165 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 IMP
    small GTPase-mediated signal transduction GO:0007264 IEA
    positive regulation of cell population proliferation GO:0008284 IMP
    insulin receptor signaling pathway GO:0008286 IBA
    insulin receptor signaling pathway GO:0008286 IMP
    response to xenobiotic stimulus GO:0009410 TAS
    positive regulation of MAPK cascade GO:0043410 IBA
    positive regulation of MAPK cascade GO:0043410 IMP
    positive regulation of GTPase activity GO:0043547 IMP
    endothelin receptor signaling pathway GO:0086100 IBA
    endothelin receptor signaling pathway GO:0086100 IMP
Subcellular Localization
    cytoplasm GO:0005737 IEA
    focal adhesion GO:0005925 ISS
    membrane GO:0016020 ISS
 Experiment description of studies that identified BCAR3 in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BCAR3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GTSE1 51512
Affinity Capture-MS Homo sapiens
2 ERBB2 2064
Protein-peptide Homo sapiens
3 KIF14 9928
Affinity Capture-MS Homo sapiens
4 PXN 5829
Proximity Label-MS Homo sapiens
5 KPNA1 3836
Two-hybrid Homo sapiens
6 CCDC57 284001
Two-hybrid Homo sapiens
7 NEDD9 4739
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 BCAR1 9564
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MYO18A 399687
Affinity Capture-MS Homo sapiens
10 KIT 3815
Reconstituted Complex Homo sapiens
11 GAST  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ARFGAP2 84364
Affinity Capture-MS Homo sapiens
13 ERBB4 2066
Reconstituted Complex Homo sapiens
14 GAS8  
Two-hybrid Homo sapiens
15 RPRD1A  
Two-hybrid Homo sapiens
16 ERBB3 2065
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
17 CREB1  
Affinity Capture-MS Homo sapiens
18 TARS 6897
Affinity Capture-MS Homo sapiens
19 OSGIN1  
Two-hybrid Homo sapiens
20 APP 351
Reconstituted Complex Homo sapiens
21 GAB1  
Reconstituted Complex Homo sapiens
22 PABPC1 26986
Affinity Capture-MS Homo sapiens
23 UBASH3A 53347
Two-hybrid Homo sapiens
24 EGFR 1956
Reconstituted Complex Homo sapiens
25 DEFA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 MET 4233
Reconstituted Complex Homo sapiens
27 IMPDH2 3615
Affinity Capture-MS Homo sapiens
28 PCDHB16  
Affinity Capture-MS Homo sapiens
29 RIOK2 55781
Affinity Capture-MS Homo sapiens
30 UBE2A  
Affinity Capture-MS Homo sapiens
31 IARS 3376
Affinity Capture-MS Homo sapiens
32 CCDC25 55246
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BCAR3 is involved
No pathways found





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