Gene description for RNASE7
Gene name ribonuclease, RNase A family, 7
Gene symbol RNASE7
Other names/aliases -
Species Homo sapiens
 Database cross references - RNASE7
ExoCarta ExoCarta_84659
Vesiclepedia VP_84659
Entrez Gene 84659
HGNC 19278
MIM 612484
UniProt Q9H1E1  
 RNASE7 identified in sEVs derived from the following tissue/cell type
Bladder cancer cells 20224111    
 Gene ontology annotations for RNASE7
Molecular Function
    lipopolysaccharide binding GO:0001530 IDA
    nucleic acid binding GO:0003676 IEA
    endonuclease activity GO:0004519 IEA
    RNA nuclease activity GO:0004540 IBA
    RNA nuclease activity GO:0004540 IDA
    protein binding GO:0005515 IPI
    peptidoglycan binding GO:0042834 IDA
Biological Process
    antibacterial humoral response GO:0019731 IDA
    innate immune response GO:0045087 IBA
    innate immune response GO:0045087 IDA
    innate immune response GO:0045087 NAS
    defense response to Gram-negative bacterium GO:0050829 IBA
    defense response to Gram-negative bacterium GO:0050829 IDA
    defense response to Gram-positive bacterium GO:0050830 IBA
    defense response to Gram-positive bacterium GO:0050830 IDA
    defense response to fungus GO:0050832 IBA
    defense response to fungus GO:0050832 IDA
    cytolysis in another organism GO:0051715 IDA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 NAS
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified RNASE7 in sEVs
1
Experiment ID 76
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors "Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A."
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
 Protein-protein interactions for RNASE7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HTR3B  
Affinity Capture-MS Homo sapiens
2 MORN3  
Affinity Capture-MS Homo sapiens
3 TRIM21 6737
Affinity Capture-MS Homo sapiens
4 DEFB106A  
Affinity Capture-MS Homo sapiens
5 IFNA4  
Affinity Capture-MS Homo sapiens
6 DTL  
Affinity Capture-MS Homo sapiens
7 RBM42  
Affinity Capture-MS Homo sapiens
8 AGPAT1 10554
Affinity Capture-MS Homo sapiens
9 SLC25A6 293
Affinity Capture-MS Homo sapiens
10 NDST2  
Affinity Capture-MS Homo sapiens
11 CCDC103  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 APTX  
Affinity Capture-MS Homo sapiens
13 AMTN  
Affinity Capture-MS Homo sapiens
14 CCNC  
Affinity Capture-MS Homo sapiens
15 FCF1  
Affinity Capture-MS Homo sapiens
16 SLCO6A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 RNH1 6050
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
20 TBC1D22B  
Affinity Capture-MS Homo sapiens
21 MBD4  
Affinity Capture-MS Homo sapiens
22 SLC35F2 54733
Affinity Capture-MS Homo sapiens
23 ZSWIM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 EPHX4 253152
Affinity Capture-MS Homo sapiens
25 ZSCAN12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 UBE3A 7337
Affinity Capture-MS Homo sapiens
27 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 C1orf35  
Affinity Capture-MS Homo sapiens
29 ZIC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PTDSS1 9791
Affinity Capture-MS Homo sapiens
31 SFR1 119392
Affinity Capture-MS Homo sapiens
32 CCDC88C 440193
Affinity Capture-MS Homo sapiens
33 FUNDC2 65991
Affinity Capture-MS Homo sapiens
34 EHBP1 23301
Affinity Capture-MS Homo sapiens
35 PI4KA 5297
Affinity Capture-MS Homo sapiens
36 C21orf59 56683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 SH2D3A  
Affinity Capture-MS Homo sapiens
38 DPPA4  
Affinity Capture-MS Homo sapiens
39 KIR3DS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 PI4KAP1  
Affinity Capture-MS Homo sapiens
41 PRSS16 10279
Affinity Capture-MS Homo sapiens
42 TEFM  
Affinity Capture-MS Homo sapiens
43 SARAF  
Affinity Capture-MS Homo sapiens
44 COA5  
Affinity Capture-MS Homo sapiens
45 PLK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ALDH3A1 218
Affinity Capture-MS Homo sapiens
47 E2F6 1876
Affinity Capture-MS Homo sapiens
48 SSUH2  
Affinity Capture-MS Homo sapiens
49 NUDT3 11165
Affinity Capture-MS Homo sapiens
50 ZNF550  
Affinity Capture-MS Homo sapiens
51 OR2A4 79541
Affinity Capture-MS Homo sapiens
52 GMCL1  
Affinity Capture-MS Homo sapiens
53 MRPL38  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 CCR1  
Affinity Capture-MS Homo sapiens
55 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
56 MMRN1 22915
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 STX17 55014
Affinity Capture-MS Homo sapiens
58 B3GALNT1 8706
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 GALNT9  
Affinity Capture-MS Homo sapiens
60 THAP10  
Affinity Capture-MS Homo sapiens
61 PHF11 51131
Affinity Capture-MS Homo sapiens
62 APIP 51074
Affinity Capture-MS Homo sapiens
63 MTHFD2L 441024
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RNASE7 is involved
PathwayEvidenceSource
Antimicrobial peptides TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome





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