Gene description for KDM2B
Gene name lysine (K)-specific demethylase 2B
Gene symbol KDM2B
Other names/aliases CXXC2
FBXL10
Fbl10
JHDM1B
PCCX2
Species Homo sapiens
 Database cross references - KDM2B
ExoCarta ExoCarta_84678
Vesiclepedia VP_84678
Entrez Gene 84678
HGNC 13610
MIM 609078
UniProt Q8NHM5  
 KDM2B identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for KDM2B
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IEA
    DNA binding GO:0003677 NAS
    transcription coregulator activity GO:0003712 IBA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    rRNA binding GO:0019843 IEA
    histone demethylase activity GO:0032452 IBA
    histone demethylase activity GO:0032452 TAS
    unmethylated CpG binding GO:0045322 IDA
    histone H3K36 demethylase activity GO:0051864 IDA
    histone H3K36me/H3K36me2 demethylase activity GO:0140680 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    chromatin remodeling GO:0006338 IBA
    chromatin remodeling GO:0006338 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    spermatogenesis GO:0007283 ISS
    midbrain-hindbrain boundary morphogenesis GO:0021555 ISS
    fourth ventricle development GO:0021592 ISS
    lateral ventricle development GO:0021670 ISS
    third ventricle development GO:0021678 ISS
    initiation of neural tube closure GO:0021993 ISS
    positive regulation of cell growth GO:0030307 IEA
    forebrain development GO:0030900 ISS
    midbrain development GO:0030901 ISS
    hindbrain development GO:0030902 ISS
    negative regulation of neuron apoptotic process GO:0043524 ISS
    embryonic camera-type eye morphogenesis GO:0048596 ISS
    positive regulation of stem cell population maintenance GO:1902459 IEA
    negative regulation of neural precursor cell proliferation GO:2000178 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    chromosome GO:0005694 IEA
    nucleolus GO:0005730 IEA
    PcG protein complex GO:0031519 IDA
 Experiment description of studies that identified KDM2B in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for KDM2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GATA1  
Proximity Label-MS Homo sapiens
2 ISX  
Proximity Label-MS Homo sapiens
3 IRF4  
Proximity Label-MS Homo sapiens
4 COIL  
Proximity Label-MS Homo sapiens
5 FEV  
Proximity Label-MS Homo sapiens
6 NFIB  
Proximity Label-MS Homo sapiens
7 Skp1a 21402
Affinity Capture-MS Mus musculus
8 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
9 GATA2  
Proximity Label-MS Homo sapiens
10 EN1  
Proximity Label-MS Homo sapiens
11 PAX2  
Proximity Label-MS Homo sapiens
12 RTFDC1  
Affinity Capture-MS Homo sapiens
13 FBRS 64319
Affinity Capture-MS Homo sapiens
14 SOX9  
Proximity Label-MS Homo sapiens
15 ELF4 2000
Proximity Label-MS Homo sapiens
16 MYOD1  
Proximity Label-MS Homo sapiens
17 PCGF2 7703
Affinity Capture-MS Homo sapiens
18 KLF8  
Proximity Label-MS Homo sapiens
19 PHC3  
Affinity Capture-MS Homo sapiens
20 E2F6 1876
Affinity Capture-MS Homo sapiens
21 POU5F1  
Affinity Capture-MS Homo sapiens
22 POLR1E  
Proximity Label-MS Homo sapiens
23 GCM1  
Proximity Label-MS Homo sapiens
24 DDX58 23586
Affinity Capture-RNA Homo sapiens
25 TEAD1  
Proximity Label-MS Homo sapiens
26 BCORL1  
Affinity Capture-MS Homo sapiens
27 ETV4  
Proximity Label-MS Homo sapiens
28 KLF4  
Proximity Label-MS Homo sapiens
29 LHX4  
Proximity Label-MS Homo sapiens
30 TLX3  
Proximity Label-MS Homo sapiens
31 CUL1 8454
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
32 KLF15  
Proximity Label-MS Homo sapiens
33 SOX5 6660
Proximity Label-MS Homo sapiens
34 YAF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 GFI1B  
Proximity Label-MS Homo sapiens
36 KLF16  
Proximity Label-MS Homo sapiens
37 HIST2H3C 126961
Affinity Capture-MS Homo sapiens
38 HNF1A  
Proximity Label-MS Homo sapiens
39 PRDM1  
Proximity Label-MS Homo sapiens
40 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
41 SOX17  
Proximity Label-MS Homo sapiens
42 RBX1 9978
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
43 CTBP1 1487
Proximity Label-MS Homo sapiens
44 TBR1  
Proximity Label-MS Homo sapiens
45 MGA  
Affinity Capture-MS Homo sapiens
46 NFIX 4784
Proximity Label-MS Homo sapiens
47 GOLGA2 2801
Proximity Label-MS Homo sapiens
48 CBX3 11335
Affinity Capture-MS Homo sapiens
49 CEBPE  
Two-hybrid Homo sapiens
50 LHX1  
Proximity Label-MS Homo sapiens
51 NFIA 4774
Proximity Label-MS Homo sapiens
52 LHX2  
Proximity Label-MS Homo sapiens
53 GATA3  
Proximity Label-MS Homo sapiens
54 GLI3 2737
Proximity Label-MS Homo sapiens
55 LHX3  
Proximity Label-MS Homo sapiens
56 CBX6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 S100B 6285
Affinity Capture-MS Homo sapiens
58 FAM9B  
Affinity Capture-MS Homo sapiens
59 LZTR1 8216
Two-hybrid Homo sapiens
60 T  
Proximity Label-MS Homo sapiens
61 L3MBTL2  
Affinity Capture-MS Homo sapiens
62 H2AFX 3014
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
63 KLF12  
Proximity Label-MS Homo sapiens
64 RYBP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 BCOR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 ACBD3 64746
Co-fractionation Homo sapiens
67 CD3EAP  
Proximity Label-MS Homo sapiens
68 SOX7  
Proximity Label-MS Homo sapiens
69 RING1 6015
Affinity Capture-MS Homo sapiens
70 TLX2  
Proximity Label-MS Homo sapiens
71 PAX6  
Proximity Label-MS Homo sapiens
72 HIST1H3C  
Biochemical Activity Bos taurus
73 HIST1H3A 8350
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
74 LHX6  
Proximity Label-MS Homo sapiens
75 SOX6  
Proximity Label-MS Homo sapiens
76 ELK3  
Proximity Label-MS Homo sapiens
77 PPARG 5468
Proximity Label-MS Homo sapiens
78 FOXI1  
Proximity Label-MS Homo sapiens
79 NR3C1 2908
Proximity Label-MS Homo sapiens
80 FOXL1  
Proximity Label-MS Homo sapiens
81 CBX2  
Affinity Capture-MS Homo sapiens
82 JUN 3725
Affinity Capture-Western Homo sapiens
83 HNF4A  
Proximity Label-MS Homo sapiens
84 PAX8  
Proximity Label-MS Homo sapiens
85 FOS 2353
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
86 MYC  
Proximity Label-MS Homo sapiens
87 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
88 PHC1  
Affinity Capture-MS Homo sapiens
89 KAT5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
90 PCGF1 84759
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
91 VSX1  
Proximity Label-MS Homo sapiens
92 RNF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
93 BMI1  
Affinity Capture-MS Homo sapiens
94 FOXQ1  
Proximity Label-MS Homo sapiens
95 KIAA0368 23392
Affinity Capture-MS Homo sapiens
96 NANOG  
Affinity Capture-MS Homo sapiens
97 MYB  
Proximity Label-MS Homo sapiens
98 NFIC 4782
Proximity Label-MS Homo sapiens
99 XRCC5 7520
Co-localization Homo sapiens
100 SOX2  
Proximity Label-MS Homo sapiens
101 UBE2D1 7321
Biochemical Activity Homo sapiens
102 TLX1  
Proximity Label-MS Homo sapiens
103 PARP1 142
Proximity Label-MS Homo sapiens
104 CENPA  
Proximity Label-MS Homo sapiens
105 SIN3A  
Affinity Capture-Western Homo sapiens
106 Pcgf1  
Affinity Capture-MS Mus musculus
107 ETV7  
Proximity Label-MS Homo sapiens
108 KLF3  
Proximity Label-MS Homo sapiens
109 SKP1 6500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
110 CREBBP  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
111 PAX9  
Proximity Label-MS Homo sapiens
112 PCGF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 KLF5  
Proximity Label-MS Homo sapiens
114 PAX7  
Proximity Label-MS Homo sapiens
115 EZH2  
Affinity Capture-Western Homo sapiens
116 GLI2  
Proximity Label-MS Homo sapiens
117 PCGF6  
Affinity Capture-MS Homo sapiens
118 CBX8 57332
Affinity Capture-MS Homo sapiens
119 ERG  
Proximity Label-MS Homo sapiens
120 HNF1B  
Proximity Label-MS Homo sapiens
121 KDM2B 84678
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
122 AR 367
Proximity Label-MS Homo sapiens
123 PHC2  
Affinity Capture-MS Homo sapiens
124 PCGF5  
Affinity Capture-MS Homo sapiens
125 ETS1  
Proximity Label-MS Homo sapiens
126 SP7  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KDM2B is involved
PathwayEvidenceSource
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
HDMs demethylate histones TAS Reactome





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