Gene description for ZFYVE19
Gene name zinc finger, FYVE domain containing 19
Gene symbol ZFYVE19
Other names/aliases ANCHR
MPFYVE
Species Homo sapiens
 Database cross references - ZFYVE19
ExoCarta ExoCarta_84936
Vesiclepedia VP_84936
Entrez Gene 84936
HGNC 20758
UniProt Q96K21  
 ZFYVE19 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ZFYVE19
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-3-phosphate binding GO:0032266 IBA
    phosphatidylinositol-3-phosphate binding GO:0032266 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    abscission GO:0009838 IBA
    negative regulation of cytokinesis GO:0032466 IMP
    mitotic cytokinesis checkpoint signaling GO:0044878 IBA
    mitotic cytokinesis checkpoint signaling GO:0044878 IMP
    midbody abscission GO:0061952 IMP
Subcellular Localization
    cytoplasm GO:0005737 IEA
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    midbody GO:0030496 IBA
    midbody GO:0030496 IDA
    cleavage furrow GO:0032154 IBA
    cleavage furrow GO:0032154 IDA
    Flemming body GO:0090543 IEA
 Experiment description of studies that identified ZFYVE19 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZFYVE19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IGBP1 3476
Co-fractionation Homo sapiens
2 SFN 2810
Co-fractionation Homo sapiens
3 ATP6V1B2 526
Co-fractionation Homo sapiens
4 TTC1 7265
Co-fractionation Homo sapiens
5 UBE2A  
Co-fractionation Homo sapiens
6 VPS4B 9525
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 AHCYL1 10768
Co-fractionation Homo sapiens
8 USP34 9736
Co-fractionation Homo sapiens
9 CCHCR1  
Two-hybrid Homo sapiens
10 TYMS 7298
Co-fractionation Homo sapiens
11 UNK  
Co-fractionation Homo sapiens
12 UBXN7 26043
Co-fractionation Homo sapiens
13 SULT1A1 6817
Co-fractionation Homo sapiens
14 UBQLN2 29978
Co-fractionation Homo sapiens
15 PAK2 5062
Co-fractionation Homo sapiens
16 UBA52 7311
Co-fractionation Homo sapiens
17 PRDX5 25824
Co-fractionation Homo sapiens
18 UBE4B 10277
Co-fractionation Homo sapiens
19 YWHAZ 7534
Co-fractionation Homo sapiens
20 USP9X 8239
Co-fractionation Homo sapiens
21 UBE2C 11065
Co-fractionation Homo sapiens
22 CAPN7 23473
Two-hybrid Homo sapiens
23 TGM2 7052
Co-fractionation Homo sapiens
24 VTA1 51534
Affinity Capture-MS Homo sapiens
25 UCHL3 7347
Co-fractionation Homo sapiens
26 PSMD13 5719
Co-fractionation Homo sapiens
27 G6PD 2539
Co-fractionation Homo sapiens
28 TRIM55  
Two-hybrid Homo sapiens
29 HTT 3064
Two-hybrid Homo sapiens
30 UBA2 10054
Co-fractionation Homo sapiens
31 LAGE3  
Co-fractionation Homo sapiens
32 YAP1 10413
Co-fractionation Homo sapiens
33 ZDHHC17 23390
Two-hybrid Homo sapiens
34 TRIM63  
Two-hybrid Homo sapiens
35 SEC24C 9632
Co-fractionation Homo sapiens
36 UBQLN4 56893
Co-fractionation Homo sapiens
37 DPY30 84661
Two-hybrid Homo sapiens
38 DSTN 11034
Co-fractionation Homo sapiens
39 TTC9C 283237
Co-fractionation Homo sapiens
40 MITD1 129531
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
41 DDX58 23586
Affinity Capture-RNA Homo sapiens
42 UBE2B 7320
Co-fractionation Homo sapiens
43 CHMP1B 57132
Affinity Capture-MS Homo sapiens
44 UBE2V2 7336
Co-fractionation Homo sapiens
45 UBXN1 51035
Co-fractionation Homo sapiens
46 UFM1 51569
Co-fractionation Homo sapiens
47 VPS4A 27183
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 UBE2D1 7321
Co-fractionation Homo sapiens
49 UFC1 51506
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which ZFYVE19 is involved
No pathways found





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