Gene description for SSNA1
Gene name Sjogren syndrome nuclear autoantigen 1
Gene symbol SSNA1
Other names/aliases N14
NA-14
NA14
Species Homo sapiens
 Database cross references - SSNA1
ExoCarta ExoCarta_8636
Vesiclepedia VP_8636
Entrez Gene 8636
HGNC 11321
MIM 610882
UniProt O43805  
 SSNA1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SSNA1
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    microtubule cytoskeleton organization GO:0000226 IDA
    microtubule cytoskeleton organization GO:0000226 ISS
    microtubule nucleation GO:0007020 IDA
    axonogenesis GO:0007409 ISS
    intraciliary transport GO:0042073 IEA
    receptor clustering GO:0043113 IEA
    axon extension GO:0048675 IBA
    axon extension GO:0048675 IMP
    axon extension GO:0048675 ISS
    cell division GO:0051301 IMP
    axon arborization GO:0140060 IMP
Subcellular Localization
    nucleus GO:0005634 IEA
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    centriole GO:0005814 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
    axoneme GO:0005930 IDA
    axon GO:0030424 IBA
    axon GO:0030424 ISS
    midbody GO:0030496 IDA
    motile cilium GO:0031514 IEA
    ciliary basal body GO:0036064 IBA
    ciliary basal body GO:0036064 IDA
    supramolecular fiber GO:0099512 IDA
 Experiment description of studies that identified SSNA1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SSNA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TXN2 25828
Two-hybrid Homo sapiens
2 POLR2M  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 SDCBP 6386
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 TCEANC  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 PGLS 25796
Co-fractionation Homo sapiens
6 DGKG  
Affinity Capture-MS Homo sapiens
7 TBC1D7  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 KIF3A 11127
Affinity Capture-MS Homo sapiens
9 ANXA3 306
Co-fractionation Homo sapiens
10 TRAF3IP1 26146
Affinity Capture-MS Homo sapiens
11 MED29  
Affinity Capture-MS Homo sapiens
12 EHHADH 1962
Two-hybrid Homo sapiens
13 FAM9B  
Affinity Capture-MS Homo sapiens
14 CDC37 11140
Two-hybrid Homo sapiens
15 TIMM10  
Affinity Capture-MS Homo sapiens
16 CTBP1 1487
Co-fractionation Homo sapiens
17 CDR2L  
Affinity Capture-MS Homo sapiens
18 CHCHD4  
Affinity Capture-MS Homo sapiens
19 PLAC9 219348
Affinity Capture-MS Homo sapiens
20 S100A4 6275
Affinity Capture-MS Homo sapiens
21 KRT38 8687
Affinity Capture-MS Homo sapiens
22 SSNA1 8636
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
23 WDYHV1  
Two-hybrid Homo sapiens
24 ITPA 3704
Co-fractionation Homo sapiens
25 SPATA2  
Affinity Capture-MS Homo sapiens
26 NUP62 23636
Affinity Capture-MS Homo sapiens
27 PSMC5 5705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 SCOC 60592
Affinity Capture-MS Homo sapiens
29 DYNLL2 140735
Affinity Capture-MS Homo sapiens
30 HSF2BP  
Affinity Capture-MS Homo sapiens
31 LCA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 S100A2 6273
Affinity Capture-MS Homo sapiens
33 LNX1  
Two-hybrid Homo sapiens
34 ESCO1  
Cross-Linking-MS (XL-MS) Homo sapiens
35 GOPC 57120
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
36 SRI 6717
Co-fractionation Homo sapiens
37 CARTPT  
Affinity Capture-MS Homo sapiens
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