Gene description for CD3G
Gene name CD3g molecule, gamma (CD3-TCR complex)
Gene symbol CD3G
Other names/aliases CD3-GAMMA
IMD17
T3G
Species Homo sapiens
 Database cross references - CD3G
ExoCarta ExoCarta_917
Vesiclepedia VP_917
Entrez Gene 917
HGNC 1675
MIM 186740
UniProt P09693  
 CD3G identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CD3G
Molecular Function
    transmembrane signaling receptor activity GO:0004888 IBA
    transmembrane signaling receptor activity GO:0004888 IC
    transmembrane signaling receptor activity GO:0004888 IMP
    protein binding GO:0005515 IPI
    signaling receptor complex adaptor activity GO:0030159 NAS
    T cell receptor binding GO:0042608 NAS
    identical protein binding GO:0042802 IDA
Biological Process
    adaptive immune response GO:0002250 NAS
    establishment or maintenance of cell polarity GO:0007163 IMP
    cell surface receptor signaling pathway GO:0007166 IBA
    cell surface receptor signaling pathway GO:0007166 IC
    cell surface receptor signaling pathway GO:0007166 IMP
    protein transport GO:0015031 IMP
    T cell activation GO:0042110 NAS
    positive thymic T cell selection GO:0045059 IBA
    gamma-delta T cell activation GO:0046629 NAS
    alpha-beta T cell activation GO:0046631 NAS
    T cell receptor signaling pathway GO:0050852 NAS
    protein-containing complex assembly GO:0065003 NAS
    regulation of lymphocyte apoptotic process GO:0070228 IMP
Subcellular Localization
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    clathrin-coated endocytic vesicle membrane GO:0030669 TAS
    alpha-beta T cell receptor complex GO:0042105 IBA
    alpha-beta T cell receptor complex GO:0042105 IDA
    alpha-beta T cell receptor complex GO:0042105 IPI
    alpha-beta T cell receptor complex GO:0042105 ISS
    gamma-delta T cell receptor complex GO:0042106 NAS
 Experiment description of studies that identified CD3G in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CD3G
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PMP22  
Two-hybrid Homo sapiens
2 TMEM186  
Affinity Capture-MS Homo sapiens
3 TMEM19  
Two-hybrid Homo sapiens
4 TMEM54  
Two-hybrid Homo sapiens
5 LAT 27040
Two-hybrid Homo sapiens
6 MAL  
Two-hybrid Homo sapiens
7 CD3E 916
Affinity Capture-Western Homo sapiens
8 NR3C1 2908
Affinity Capture-Western Homo sapiens
9 FYN 2534
Affinity Capture-Western Homo sapiens
10 LMBR1  
Affinity Capture-MS Homo sapiens
11 TMEM203  
Two-hybrid Homo sapiens
12 TMEM262  
Two-hybrid Homo sapiens
13 KTN1 3895
Two-hybrid Homo sapiens
14 HKDC1 80201
Affinity Capture-MS Homo sapiens
15 EMP1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CD3G is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Anti-inflammatory response favouring Leishmania parasite infection TAS Reactome
Cargo recognition for clathrin-mediated endocytosis TAS Reactome
Clathrin-mediated endocytosis TAS Reactome
Costimulation by the CD28 family TAS Reactome
Disease TAS Reactome
Downstream TCR signaling TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis IEA Reactome
FCGR activation IEA Reactome
FCGR activation TAS Reactome
FCGR3A-mediated IL10 synthesis TAS Reactome
FCGR3A-mediated phagocytosis TAS Reactome
Generation of second messenger molecules TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TAS Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Leishmania infection TAS Reactome
Leishmania parasite growth and survival TAS Reactome
Leishmania phagocytosis TAS Reactome
Membrane Trafficking TAS Reactome
Parasite infection TAS Reactome
Parasitic Infection Pathways TAS Reactome
PD-1 signaling TAS Reactome
Phosphorylation of CD3 and TCR zeta chains TAS Reactome
Regulation of actin dynamics for phagocytic cup formation TAS Reactome
Role of phospholipids in phagocytosis TAS Reactome
TCR signaling TAS Reactome
Translocation of ZAP-70 to Immunological synapse TAS Reactome
Vesicle-mediated transport TAS Reactome





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