Gene description for LDHAL6B
Gene name lactate dehydrogenase A-like 6B
Gene symbol LDHAL6B
Other names/aliases LDH6B
LDHAL6
LDHL
Species Homo sapiens
 Database cross references - LDHAL6B
ExoCarta ExoCarta_92483
Vesiclepedia VP_92483
Entrez Gene 92483
HGNC 21481
UniProt Q9BYZ2  
 LDHAL6B identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Squamous carcinoma cells 20124223    
 Gene ontology annotations for LDHAL6B
Molecular Function
    L-lactate dehydrogenase activity GO:0004459 IBA
    L-lactate dehydrogenase activity GO:0004459 TAS
    protein binding GO:0005515 IPI
Biological Process
    lactate metabolic process GO:0006089 IBA
    lactate metabolic process GO:0006089 IDA
    pyruvate metabolic process GO:0006090 IBA
    pyruvate metabolic process GO:0006090 IDA
    pyruvate metabolic process GO:0006090 TAS
Subcellular Localization
    nucleus GO:0005634 HDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IBA
    mitochondrial matrix GO:0005759 TAS
    oxidoreductase complex GO:1990204 NAS
 Experiment description of studies that identified LDHAL6B in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LDHAL6B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF276 92822
Affinity Capture-MS Homo sapiens
2 NAGK 55577
Co-fractionation Homo sapiens
3 HSPA5 3309
Affinity Capture-MS Homo sapiens
4 ACSF2 80221
Affinity Capture-MS Homo sapiens
5 GDA 9615
Co-fractionation Homo sapiens
6 SOD1 6647
Co-fractionation Homo sapiens
7 TP53 7157
Affinity Capture-MS Homo sapiens
8 WDR1 9948
Co-fractionation Homo sapiens
9 MTIF2 4528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 LDHA 3939
Co-fractionation Homo sapiens
11 TALDO1 6888
Co-fractionation Homo sapiens
12 ARF5 381
Co-fractionation Homo sapiens
13 GNS 2799
Co-fractionation Homo sapiens
14 DNLZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PRMT6  
Two-hybrid Homo sapiens
16 PPOX 5498
Affinity Capture-MS Homo sapiens
17 MCCC1 56922
Affinity Capture-MS Homo sapiens
18 TARS2 80222
Affinity Capture-MS Homo sapiens
19 TKT 7086
Co-fractionation Homo sapiens
20 BCCIP 56647
Co-fractionation Homo sapiens
21 TMLHE 55217
Affinity Capture-MS Homo sapiens
22 SORD 6652
Co-fractionation Homo sapiens
23 RAB1A 5861
Co-fractionation Homo sapiens
24 CPS1 1373
Affinity Capture-MS Homo sapiens
25 PRMT5 10419
Two-hybrid Homo sapiens
26 ABAT  
Co-fractionation Homo sapiens
27 BAG1 573
Affinity Capture-MS Homo sapiens
28 APBB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 TPI1 7167
Co-fractionation Homo sapiens
30 SLC9A3R1 9368
Co-fractionation Homo sapiens
31 ARF1 375
Co-fractionation Homo sapiens
32 KYNU  
Co-fractionation Homo sapiens
33 SUV39H1  
Two-hybrid Homo sapiens
34 RAB5C 5878
Co-fractionation Homo sapiens
35 SMS 6611
Co-fractionation Homo sapiens
36 CAPN1 823
Co-fractionation Homo sapiens
37 MDH1 4190
Co-fractionation Homo sapiens
38 ARF4 378
Co-fractionation Homo sapiens
39 ECHDC3 79746
Affinity Capture-MS Homo sapiens
40 ABCB8 11194
Co-fractionation Homo sapiens
41 ALDH4A1 8659
Co-fractionation Homo sapiens
42 PEPD 5184
Co-fractionation Homo sapiens
43 DARS2 55157
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LDHAL6B is involved
PathwayEvidenceSource
Aerobic respiration and respiratory electron transport TAS Reactome
Metabolism TAS Reactome
Pyruvate metabolism TAS Reactome





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