Gene description for Fgg
Gene name fibrinogen gamma chain
Gene symbol Fgg
Other names/aliases 3010002H13Rik
AI256424
Species Mus musculus
 Database cross references - Fgg
ExoCarta ExoCarta_99571
Vesiclepedia VP_99571
Entrez Gene 99571
UniProt Q8VCM7  
 Fgg identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Fgg
Molecular Function
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 IEA
    signaling receptor binding GO:0005102 ISO
    structural molecule activity GO:0005198 ISO
    extracellular matrix structural constituent GO:0005201 RCA
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
    cell adhesion molecule binding GO:0050839 ISO
Biological Process
    adaptive immune response GO:0002250 IEA
    cell-matrix adhesion GO:0007160 IBA
    cell-matrix adhesion GO:0007160 ISO
    protein secretion GO:0009306 ISO
    platelet activation GO:0030168 IEA
    plasminogen activation GO:0031639 ISO
    positive regulation of heterotypic cell-cell adhesion GO:0034116 ISO
    fibrinolysis GO:0042730 ISO
    innate immune response GO:0045087 IEA
    positive regulation of vasoconstriction GO:0045907 ISO
    positive regulation of exocytosis GO:0045921 ISO
    positive regulation of protein secretion GO:0050714 ISO
    protein polymerization GO:0051258 IEA
    protein polymerization GO:0051258 ISO
    response to calcium ion GO:0051592 ISO
    protein-containing complex assembly GO:0065003 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    platelet aggregation GO:0070527 IBA
    platelet aggregation GO:0070527 ISO
    blood coagulation, fibrin clot formation GO:0072378 ISO
    positive regulation of peptide hormone secretion GO:0090277 ISO
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 ISO
    negative regulation of endothelial cell apoptotic process GO:2000352 ISO
Subcellular Localization
    fibrinogen complex GO:0005577 IEA
    fibrinogen complex GO:0005577 ISO
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    cell cortex GO:0005938 IDA
    external side of plasma membrane GO:0009897 ISO
    cell surface GO:0009986 ISO
    platelet alpha granule GO:0031091 ISO
    synapse GO:0045202 EXP
    synapse GO:0045202 IDA
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 IBA
    blood microparticle GO:0072562 ISO
 Experiment description of studies that identified Fgg in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Fgg
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 F13a1 74145
Co-fractionation Mus musculus
2 Thbs1 21825
Co-fractionation Mus musculus
3 Fancd2  
Affinity Capture-MS Mus musculus
4 Kctd13  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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