Gene description for Lrrc19
Gene name leucine rich repeat containing 19
Gene symbol Lrrc19
Other names/aliases 9130022A01Rik
AI314124
AL022954
AW261791
Species Mus musculus
 Database cross references - Lrrc19
ExoCarta ExoCarta_100061
Vesiclepedia VP_100061
Entrez Gene 100061
UniProt Q8BZT5  
 Lrrc19 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Lrrc19
Molecular Function
    signaling receptor activity GO:0038023 IBA
    signaling receptor activity GO:0038023 IDA
Biological Process
    regulation of cytokine production GO:0001817 IMP
    toll-like receptor signaling pathway GO:0002224 IBA
    toll-like receptor signaling pathway GO:0002224 IDA
    interleukin-8 production GO:0032637 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IMP
    host-mediated regulation of intestinal microbiota composition GO:0048874 IMP
    regulation of inflammatory response GO:0050727 IMP
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IBA
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IDA
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified Lrrc19 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Lrrc19
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lrrc19 is involved
No pathways found





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