Gene description for APOA4
Gene name apolipoprotein A-IV
Gene symbol APOA4
Other names/aliases -
Species Equus caballus
 Database cross references - APOA4
ExoCarta ExoCarta_100062506
Vesiclepedia VP_100062506
Entrez Gene 100062506
UniProt None  
 APOA4 identified in exosomes derived from the following tissue/cell type
Follicular fluid 22116803    
 Gene ontology annotations for APOA4
Molecular Function
    phosphatidylcholine binding GO:0031210 IEA
    phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 IEA
Biological Process
    positive regulation of triglyceride catabolic process GO:0010898 IEA
    regulation of intestinal cholesterol absorption GO:0030300 IEA
    cholesterol efflux GO:0033344 IEA
    phospholipid efflux GO:0033700 IEA
    very-low-density lipoprotein particle remodeling GO:0034372 IEA
    lipoprotein metabolic process GO:0042157 IEA
    cholesterol homeostasis GO:0042632 IEA
    reverse cholesterol transport GO:0043691 IEA
    positive regulation of fatty acid biosynthetic process GO:0045723 IEA
    phosphatidylcholine metabolic process GO:0046470 IEA
    positive regulation of lipoprotein lipase activity GO:0051006 IEA
    triglyceride homeostasis GO:0070328 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    high-density lipoprotein particle GO:0034364 IEA
    chylomicron GO:0042627 IEA
    blood microparticle GO:0072562 IEA
 Experiment description of studies that identified APOA4 in exosomes
1
Experiment ID 147
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|CD63
Enriched markers
✔
cytochrome c
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22116803    
Organism Equus caballus
Experiment description Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle
Authors da Silveira JC, Veeramachaneni DN, Winger QA, Carnevale EM, Bouma GJ
Journal name Biol Reprod
Publication year 2011
Sample Follicular fluid
Sample name Follicular fluid - Ovarian - Young mare
Isolation/purification methods Differential centrifugation
Exoquick
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
RT-PCR
Mass spectrometry [LTQ]
 Protein-protein interactions for APOA4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which APOA4 is involved
No pathways found





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