Gene description for RAPGEF2
Gene name Rap guanine nucleotide exchange factor (GEF) 2
Gene symbol RAPGEF2
Other names/aliases PDZ-GEF1
nRap GEP
Species Bos taurus
 Database cross references - RAPGEF2
ExoCarta ExoCarta_100139484
Entrez Gene 100139484
UniProt F1MSG6  
 RAPGEF2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for RAPGEF2
Molecular Function
    protein binding GO:0005515 IPI
    WW domain binding GO:0050699 ISS
    beta-1 adrenergic receptor binding GO:0031697 ISS
    Rap guanyl-nucleotide exchange factor activity GO:0017034 ISS
    PDZ domain binding GO:0030165 ISS
    phosphatidic acid binding GO:0070300 IEA
    Ras guanyl-nucleotide exchange factor activity GO:0005088 ISS
    cAMP binding GO:0030552 ISS
    GTPase activator activity GO:0005096 IEA
Biological Process
    positive regulation of vasculogenesis GO:2001214 ISS
    establishment of endothelial barrier GO:0061028 ISS
    cellular response to nerve growth factor stimulus GO:1990090 ISS
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 ISS
    neuron migration GO:0001764 ISS
    regulation of cell junction assembly GO:1901888 ISS
    positive regulation of dendritic cell apoptotic process GO:2000670 ISS
    blood vessel development GO:0001568 ISS
    negative regulation of cell proliferation GO:0008285 ISS
    adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 ISS
    microvillus assembly GO:0030033 IEA
    positive regulation of cAMP-dependent protein kinase activity GO:2000481 ISS
    cellular response to cAMP GO:0071320 ISS
    establishment of endothelial intestinal barrier GO:0090557 IEA
    protein localization to plasma membrane GO:0072659 IEA
    G-protein coupled receptor signaling pathway GO:0007186 ISS
    neuron projection development GO:0031175 ISS
    negative regulation of melanin biosynthetic process GO:0048022 ISS
    forebrain neuron development GO:0021884 ISS
    positive regulation of neuron migration GO:2001224 ISS
    positive regulation of neuron projection development GO:0010976 ISS
    negative regulation of dendrite morphogenesis GO:0050774 ISS
    neuropeptide signaling pathway GO:0007218 ISS
    cAMP-mediated signaling GO:0019933 ISS
    Rap protein signal transduction GO:0032486 ISS
    ventricular system development GO:0021591 ISS
    nerve growth factor signaling pathway GO:0038180 ISS
    positive regulation of GTPase activity GO:0043547 ISS
    cellular response to cGMP GO:0071321 ISS
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS
    positive regulation of cAMP-mediated signaling GO:0043950 ISS
    positive regulation of protein binding GO:0032092 ISS
    positive regulation of protein kinase activity GO:0045860 ISS
Subcellular Localization
    neuron projection GO:0043005 ISS
    late endosome GO:0005770 ISS
    neuronal cell body GO:0043025 ISS
    cell-cell junction GO:0005911 ISS
    bicellular tight junction GO:0005923 IEA
    plasma membrane GO:0005886 ISS
    protein complex GO:0043234 ISS
    endocytic vesicle GO:0030139 IEA
    cytoplasm GO:0005737 ISS
    apical plasma membrane GO:0016324 IEA
    synapse GO:0045202 ISS
    cytosol GO:0005829 IEA
    perinuclear region of cytoplasm GO:0048471 ISS
 Experiment description of studies that identified RAPGEF2 in exosomes
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RAPGEF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RAPGEF2 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here