Gene description for PRKAR2A
Gene name protein kinase, cAMP-dependent, regulatory, type II, alpha
Gene symbol PRKAR2A
Other names/aliases -
Species Bos taurus
 Database cross references - PRKAR2A
ExoCarta ExoCarta_100139910
Vesiclepedia VP_100139910
Entrez Gene 100139910
UniProt P00515  
 PRKAR2A identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PRKAR2A
Molecular Function
    cAMP-dependent protein kinase regulator activity GO:0008603 IEA
Biological Process
    regulation of protein phosphorylation GO:0001932 IEA
Subcellular Localization
    cAMP-dependent protein kinase complex GO:0005952 IEA
 Experiment description of studies that identified PRKAR2A in exosomes
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PRKAR2A
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PRKAR2A is involved
PathwayEvidenceSource
Activation of NMDA receptors and postsynaptic events IEA Reactome
Aquaporin-mediated transport IEA Reactome
Ca-dependent events IEA Reactome
Calmodulin induced events IEA Reactome
CaM pathway IEA Reactome
Cellular responses to mechanical stimuli IEA Reactome
Cellular responses to stimuli IEA Reactome
CREB1 phosphorylation through the activation of Adenylate Cyclase IEA Reactome
DAG and IP3 signaling IEA Reactome
DARPP-32 events IEA Reactome
Factors involved in megakaryocyte development and platelet production IEA Reactome
G alpha (i) signalling events IEA Reactome
G alpha (s) signalling events IEA Reactome
G-protein mediated events IEA Reactome
Glucagon signaling in metabolic regulation IEA Reactome
GPCR downstream signalling IEA Reactome
GPER1 signaling IEA Reactome
Hedgehog 'off' state IEA Reactome
Hemostasis IEA Reactome
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells IEA Reactome
Integration of energy metabolism IEA Reactome
Intracellular signaling by second messengers IEA Reactome
Metabolism IEA Reactome
Neuronal System IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
Opioid Signalling IEA Reactome
PKA activation IEA Reactome
PKA activation in glucagon signalling IEA Reactome
PKA-mediated phosphorylation of CREB IEA Reactome
PLC beta mediated events IEA Reactome
Post NMDA receptor activation events IEA Reactome
Response of endothelial cells to shear stress IEA Reactome
Signal Transduction IEA Reactome
Signaling by GPCR IEA Reactome
Signaling by Hedgehog IEA Reactome
Transmission across Chemical Synapses IEA Reactome
Transport of small molecules IEA Reactome
Vasopressin regulates renal water homeostasis via Aquaporins IEA Reactome





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