Gene description for ABCC9
Gene name ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Gene symbol ABCC9
Other names/aliases ABC37
ATFB12
CANTU
CMD1O
SUR2
Species Homo sapiens
 Database cross references - ABCC9
ExoCarta ExoCarta_10060
Vesiclepedia VP_10060
Entrez Gene 10060
HGNC 60
MIM 601439
UniProt O60706  
 ABCC9 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Urine 19056867    
 Gene ontology annotations for ABCC9
Molecular Function
    potassium channel activity GO:0005267 IMP
    ATP binding GO:0005524 IEA
    sulfonylurea receptor activity GO:0008281 ISS
    ATP-activated inward rectifier potassium channel activity GO:0015272 NAS
    potassium channel regulator activity GO:0015459 ISS
    ATP hydrolysis activity GO:0016887 IEA
    ATPase-coupled monoatomic cation transmembrane transporter activity GO:0019829 ISS
    ATPase-coupled transmembrane transporter activity GO:0042626 IBA
    ATPase-coupled transmembrane transporter activity GO:0042626 IDA
    ATPase-coupled inorganic anion transmembrane transporter activity GO:0043225 TAS
    transmembrane transporter binding GO:0044325 IPI
    protein-containing complex binding GO:0044877 IEA
    potassium channel activator activity GO:0099104 ISS
    ABC-type transporter activity GO:0140359 IEA
Biological Process
    MAPK cascade GO:0000165 IEA
    action potential GO:0001508 IEA
    response to hypoxia GO:0001666 IEA
    heart morphogenesis GO:0003007 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    mitochondrion organization GO:0007005 IEA
    skeletal muscle tissue development GO:0007519 IEA
    gene expression GO:0010467 IEA
    response to activity GO:0014823 IEA
    fatty acid oxidation GO:0019395 IEA
    response to ATP GO:0033198 IMP
    response to ATP GO:0033198 ISS
    cellular response to potassium ion GO:0035865 IEA
    vasodilation GO:0042311 IEA
    response to hydrogen peroxide GO:0042542 IEA
    negative regulation of apoptotic process GO:0043066 IEA
    response to estrogen GO:0043627 IEA
    cellular respiration GO:0045333 IEA
    negative regulation of blood pressure GO:0045776 IEA
    ATP metabolic process GO:0046034 IEA
    fibroblast proliferation GO:0048144 IEA
    defense response to virus GO:0051607 IMP
    transmembrane transport GO:0055085 IBA
    transmembrane transport GO:0055085 TAS
    coronary vasculature development GO:0060976 IEA
    cardiac conduction GO:0061337 IMP
    cellular response to chemical stress GO:0062197 IEA
    cellular response to calcium ion GO:0071277 IEA
    cellular response to ATP GO:0071318 IEA
    cellular response to xenobiotic stimulus GO:0071466 IEA
    potassium ion transmembrane transport GO:0071805 IMP
    potassium ion transmembrane transport GO:0071805 NAS
    oxygen metabolic process GO:0072592 IEA
    cardiac muscle cell contraction GO:0086003 IEA
    monoatomic cation transmembrane transport GO:0098655 ISS
    monoatomic anion transmembrane transport GO:0098656 IEA
    inorganic cation transmembrane transport GO:0098662 ISS
    transport across blood-brain barrier GO:0150104 NAS
    regulation of potassium ion transmembrane transport GO:1901379 IEA
    response to peptide GO:1901652 IEA
    reactive oxygen species biosynthetic process GO:1903409 IEA
    response to hydrogen sulfide GO:1904880 IEA
    potassium ion import across plasma membrane GO:1990573 ISO
    potassium ion import across plasma membrane GO:1990573 ISS
Subcellular Localization
    mitochondrion GO:0005739 IEA
    plasma membrane GO:0005886 TAS
    inward rectifying potassium channel GO:0008282 IDA
    inward rectifying potassium channel GO:0008282 ISO
    inward rectifying potassium channel GO:0008282 ISS
    membrane GO:0016020 IBA
    sarcomere GO:0030017 IEA
    potassium ion-transporting ATPase complex GO:0031004 ISS
    sarcolemma GO:0042383 IEA
 Experiment description of studies that identified ABCC9 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 224
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
6
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ABCC9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPB2  
Two-hybrid Homo sapiens
2 BKRF1  
Affinity Capture-MS
3 ABCC8  
Affinity Capture-MS Homo sapiens
4 EEF1G 1937
Two-hybrid Homo sapiens
5 LDHA 3939
Affinity Capture-Western Homo sapiens
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