Gene description for ABCC9
Gene name ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Gene symbol ABCC9
Other names/aliases ABC37
ATFB12
CANTU
CMD1O
SUR2
Species Homo sapiens
 Database cross references - ABCC9
ExoCarta ExoCarta_10060
Entrez Gene 10060
HGNC 60
MIM 601439
UniProt O60706  
 ABCC9 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Urine 19056867    
 Gene ontology annotations for ABCC9
Molecular Function
    ATP binding GO:0005524 IEA
    potassium channel regulator activity GO:0015459 ISS
    ATPase activity, coupled to transmembrane movement of substances GO:0042626 IEA
    sulfonylurea receptor activity GO:0008281 ISS
    transporter activity GO:0005215 TAS
    potassium channel activity GO:0005267 IEA
    ion channel binding GO:0044325 IPI
Biological Process
    signal transduction GO:0007165 TAS
    synaptic transmission GO:0007268 TAS
    potassium ion transport GO:0006813 TAS
    transmembrane transport GO:0055085 TAS
    potassium ion import GO:0010107 ISS
    defense response to virus GO:0051607 IMP
    metabolic process GO:0008152 IEA
Subcellular Localization
    voltage-gated potassium channel complex GO:0008076 IDA
    sarcomere GO:0030017 IEA
    ATP-sensitive potassium channel complex GO:0008282 ISS
    sarcolemma GO:0042383 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified ABCC9 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ABCC9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EEF1G 1937
Two-hybrid Homo sapiens
2 KCNJ8  
Invitro Homo sapiens
3 LDHA 3939
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ABCC9 is involved
PathwayEvidenceSource
ABC-family proteins mediated transport TAS Reactome
ATP sensitive Potassium channels TAS Reactome





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