Gene description for Psph
Gene name phosphoserine phosphatase
Gene symbol Psph
Other names/aliases AI480570
PSP
PSPase
Species Mus musculus
 Database cross references - Psph
ExoCarta ExoCarta_100678
Entrez Gene 100678
UniProt Q99LS3  
 Psph identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Psph
Molecular Function
    phosphoserine phosphatase activity GO:0004647 ISO
    metal ion binding GO:0046872 IEA
    hydrolase activity GO:0016787 IEA
    magnesium ion binding GO:0000287 ISO
    protein homodimerization activity GO:0042803 ISO
    phosphatase activity GO:0016791 IEA
    calcium ion binding GO:0005509 ISO
Biological Process
    cellular amino acid biosynthetic process GO:0008652 IEA
    dephosphorylation GO:0016311 ISO
    L-serine metabolic process GO:0006563 ISO
    L-serine biosynthetic process GO:0006564 IBA
    metabolic process GO:0008152 IEA
Subcellular Localization
    neuron projection GO:0043005 ISO
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified Psph in exosomes
1
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Psph
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Psph is involved
PathwayEvidenceSource
Serine biosynthesis IEA Reactome





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