Gene description for Ube3c
Gene name ubiquitin protein ligase E3C
Gene symbol Ube3c
Other names/aliases AI853514
mKIAA0010
Species Mus musculus
 Database cross references - Ube3c
ExoCarta ExoCarta_100763
Vesiclepedia VP_100763
Entrez Gene 100763
UniProt Q80U95  
 Ube3c identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ube3c
Molecular Function
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 ISO
    ubiquitin protein ligase activity GO:0061630 ISS
Biological Process
    protein polyubiquitination GO:0000209 IBA
    protein polyubiquitination GO:0000209 ISO
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 ISO
    protein K29-linked ubiquitination GO:0035519 ISO
    protein K29-linked ubiquitination GO:0035519 ISS
    protein K48-linked ubiquitination GO:0070936 ISO
    protein K48-linked ubiquitination GO:0070936 ISS
 Experiment description of studies that identified Ube3c in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ube3c
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cand2  
Co-fractionation Mus musculus
2 Ocln  
Co-fractionation Mus musculus
3 Ubc  
Reconstituted Complex Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Pank4  
Co-fractionation Mus musculus
6 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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