Gene description for Ube3c
Gene name ubiquitin protein ligase E3C
Gene symbol Ube3c
Other names/aliases AI853514
Species Mus musculus
 Database cross references - Ube3c
ExoCarta ExoCarta_100763
Entrez Gene 100763
UniProt Q80U95  
 Ube3c identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ube3c
Molecular Function
    protein-glycine ligase activity GO:0070735 IEA
    protein-glycine ligase activity, initiating GO:0070736 IEA
    coenzyme F420-0 gamma-glutamyl ligase activity GO:0043773 IEA
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GO:0008766 IEA
    ubiquitin-protein transferase activity GO:0004842 ISO
    ligase activity GO:0016874 IEA
    tubulin-glutamic acid ligase activity GO:0070740 IEA
    coenzyme F420-2 alpha-glutamyl ligase activity GO:0043774 IEA
    tubulin-glycine ligase activity GO:0070738 IEA
    protein-glutamic acid ligase activity GO:0070739 IEA
    protein-glycine ligase activity, elongating GO:0070737 IEA
    ribosomal S6-glutamic acid ligase activity GO:0018169 IEA
Biological Process
    protein polyubiquitination GO:0000209 ISO
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Ube3c in exosomes
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Ube3c
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ube3c is involved
Antigen processing: Ubiquitination & Proteasome degradation IEA Reactome

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