Gene description for Myh9
Gene name myosin, heavy chain 9, non-muscle
Gene symbol Myh9
Other names/aliases NMMHC II-a
NMMHC-A
NMMHC-IIA
Species Rattus norvegicus
 Database cross references - Myh9
ExoCarta ExoCarta_100911597
Entrez Gene 100911597
 Myh9 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Myh9
Molecular Function
    protein binding GO:0005515 IPI
    microfilament motor activity GO:0000146 ISS
    ADP binding GO:0043531 ISO
    motor activity GO:0003774 IEA
    protein homodimerization activity GO:0042803 ISS
    calmodulin binding GO:0005516 IEA
    poly(A) RNA binding GO:0044822 ISO
    actin filament binding GO:0051015 ISS
    protein domain specific binding GO:0019904 ISO
    sodium:potassium-exchanging ATPase activity GO:0005391 ISS
    actin binding GO:0003779 ISO
    actin-dependent ATPase activity GO:0030898 ISO
    ATP binding GO:0005524 ISO
    protein anchor GO:0043495 ISS
    ATPase activity GO:0016887 ISS
Biological Process
    uropod organization GO:0032796 ISO
    sodium ion transmembrane transport GO:0035725 ISS
    protein transport GO:0015031 ISS
    actin cytoskeleton reorganization GO:0031532 ISS
    in utero embryonic development GO:0001701 ISO
    blood vessel endothelial cell migration GO:0043534 ISS
    negative regulation of actin filament severing GO:1903919 ISO
    establishment of meiotic spindle localization GO:0051295 ISO
    actomyosin structure organization GO:0031032 ISO
    platelet formation GO:0030220 ISS
    platelet aggregation GO:0070527 ISO
    single organismal cell-cell adhesion GO:0016337 ISO
    phagocytosis, engulfment GO:0006911 ISO
    membrane protein ectodomain proteolysis GO:0006509 ISS
    meiotic spindle organization GO:0000212 ISO
    monocyte differentiation GO:0030224 ISS
    positive regulation of protein processing in phagocytic vesicle GO:1903923 ISO
    angiogenesis GO:0001525 ISS
    actin filament polymerization GO:0030041 ISO
    cell adhesion GO:0007155 ISO
    actin filament-based movement GO:0030048 ISS
    regulation of cell shape GO:0008360 ISS
    cell morphogenesis involved in differentiation GO:0000904 ISO
    establishment of T cell polarity GO:0001768 ISO
    metabolic process GO:0008152 IEA
    myoblast fusion GO:0007520 ISO
    actin filament capping GO:0051693 ISO
Subcellular Localization
    brush border GO:0005903 ISO
    cell-cell adherens junction GO:0005913 ISO
    cleavage furrow GO:0032154 ISS
    COP9 signalosome GO:0008180 ISO
    protein complex GO:0043234 ISS
    cell leading edge GO:0031252 ISS
    extracellular exosome GO:0070062 ISO
    cytosol GO:0005829 ISS
    focal adhesion GO:0005925 ISO
    myosin II complex GO:0016460 ISO
    stress fiber GO:0001725 ISS
    cytoplasm GO:0005737 ISS
    myosin complex GO:0016459 ISO
    spindle GO:0005819 ISO
    actomyosin contractile ring GO:0005826 ISS
    neuromuscular junction GO:0031594 ISO
    integrin complex GO:0008305 ISS
    cortical cytoskeleton GO:0030863 ISO
    nucleus GO:0005634 ISS
    immunological synapse GO:0001772 ISO
    actomyosin GO:0042641 ISO
    plasma membrane GO:0005886 ISS
    myosin II filament GO:0097513 ISO
    ruffle GO:0001726 ISS
    uropod GO:0001931 ISO
    cell cortex GO:0005938 ISO
    membrane GO:0016020 ISO
    actin cytoskeleton GO:0015629 ISS
 Experiment description of studies that identified Myh9 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Myh9
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Myh9 is involved
No pathways found





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