Gene description for Adamts9
Gene name a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9
Gene symbol Adamts9
Other names/aliases 1810011L16Rik
8430403M15Rik
AW743315
E030027K14Rik
Species Mus musculus
 Database cross references - Adamts9
ExoCarta ExoCarta_101401
Vesiclepedia VP_101401
Entrez Gene 101401
 Adamts9 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Adamts9
Molecular Function
    endopeptidase activity GO:0004175 IDA
    metalloendopeptidase activity GO:0004222 IBA
    metalloendopeptidase activity GO:0004222 IEA
    metallopeptidase activity GO:0008237 ISO
    zinc ion binding GO:0008270 IEA
Biological Process
    lens development in camera-type eye GO:0002088 IMP
    heart valve morphogenesis GO:0003179 IMP
    ventricular cardiac muscle tissue development GO:0003229 IMP
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 IDA
    proteolysis GO:0006508 ISO
    response to bacterium GO:0009617 IEP
    negative regulation of endothelial cell migration GO:0010596 IMP
    extracellular matrix organization GO:0030198 IBA
    extracellular matrix organization GO:0030198 IMP
    melanocyte differentiation GO:0030318 IGI
    aorta morphogenesis GO:0035909 IMP
    positive regulation of melanocyte differentiation GO:0045636 IGI
    regulation of developmental pigmentation GO:0048070 IGI
    camera-type eye morphogenesis GO:0048593 IMP
    cornea development in camera-type eye GO:0061303 IMP
    endothelial cell-matrix adhesion GO:0090673 IMP
    negative regulation of sprouting angiogenesis GO:1903671 IMP
Subcellular Localization
    extracellular space GO:0005615 IDA
    endoplasmic reticulum GO:0005783 ISO
    cell surface GO:0009986 IDA
    extracellular matrix GO:0031012 IBA
    extracellular matrix GO:0031012 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Adamts9 in exosomes
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Adamts9
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adamts9 is involved
No pathways found





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