Gene description for Nlrp6
Gene name NLR family, pyrin domain containing 6
Gene symbol Nlrp6
Other names/aliases AI504961
Avr
Nalp6
Navr
Navr/Avr
Pypaf5
Species Mus musculus
 Database cross references - Nlrp6
ExoCarta ExoCarta_101613
Entrez Gene 101613
UniProt Q91WS2  
 Nlrp6 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nlrp6
Molecular Function
    ATP binding GO:0005524 IEA
    peptide binding GO:0042277 ISO
    nucleotide binding GO:0000166 IEA
    vasopressin receptor activity GO:0005000 ISO
Biological Process
    negative regulation of immune response GO:0050777 IMP
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IMP
    wound healing GO:0042060 IMP
    negative regulation of toll-like receptor signaling pathway GO:0034122 IMP
    negative regulation of MAPK cascade GO:0043409 IMP
    regulation of mucus secretion GO:0070255 IMP
    G-protein coupled receptor signaling pathway GO:0007186 ISO
    response to bacterium GO:0009617 IMP
    regulation of inflammatory response GO:0050727 IMP
    regulation of autophagy GO:0010506 IMP
Subcellular Localization
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 IEA
    cellular_component GO:0005575 ND
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Nlrp6 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nlrp6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nlrp6 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here