Gene description for Nlrp6
Gene name NLR family, pyrin domain containing 6
Gene symbol Nlrp6
Other names/aliases AI504961
Avr
Nalp6
Navr
Navr/Avr
Pypaf5
Species Mus musculus
 Database cross references - Nlrp6
ExoCarta ExoCarta_101613
Vesiclepedia VP_101613
Entrez Gene 101613
UniProt Q91WS2  
 Nlrp6 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nlrp6
Molecular Function
    lipopolysaccharide binding GO:0001530 ISO
    lipopolysaccharide binding GO:0001530 ISS
    double-stranded RNA binding GO:0003725 IDA
    double-stranded RNA binding GO:0003725 ISO
    double-stranded RNA binding GO:0003725 ISS
    vasopressin receptor activity GO:0005000 IBA
    vasopressin receptor activity GO:0005000 ISO
    vasopressin receptor activity GO:0005000 ISS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    signaling adaptor activity GO:0035591 IEA
    signaling adaptor activity GO:0035591 ISO
    pattern recognition receptor activity GO:0038187 IDA
    pattern recognition receptor activity GO:0038187 ISO
    peptide binding GO:0042277 IBA
    peptide binding GO:0042277 ISO
    lipoteichoic acid binding GO:0070891 IDA
    lipoteichoic acid binding GO:0070891 ISO
    molecular condensate scaffold activity GO:0140693 IDA
    molecular condensate scaffold activity GO:0140693 ISO
Biological Process
    acute inflammatory response to antigenic stimulus GO:0002438 IMP
    acute inflammatory response GO:0002526 IBA
    acute inflammatory response GO:0002526 IMP
    negative regulation of inflammatory response to antigenic stimulus GO:0002862 IMP
    G protein-coupled receptor signaling pathway GO:0007186 IEA
    response to bacterium GO:0009617 IMP
    regulation of autophagy GO:0010506 IMP
    interleukin-1 beta production GO:0032611 IMP
    interleukin-18 production GO:0032621 IMP
    negative regulation of type II interferon production GO:0032689 IMP
    negative regulation of toll-like receptor signaling pathway GO:0034122 IMP
    wound healing GO:0042060 IMP
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IMP
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IMP
    negative regulation of MAPK cascade GO:0043409 IMP
    host-mediated regulation of intestinal microbiota composition GO:0048874 IMP
    host-mediated regulation of intestinal microbiota composition GO:0048874 IMP
    regulation of inflammatory response GO:0050727 IBA
    regulation of inflammatory response GO:0050727 IMP
    regulation of inflammatory response GO:0050727 IMP
    positive regulation of inflammatory response GO:0050729 IDA
    positive regulation of inflammatory response GO:0050729 ISO
    negative regulation of immune response GO:0050777 IMP
    defense response to Gram-positive bacterium GO:0050830 IDA
    defense response to Gram-positive bacterium GO:0050830 ISO
    protein homooligomerization GO:0051260 IDA
    protein homooligomerization GO:0051260 ISO
    defense response to virus GO:0051607 IMP
    defense response to virus GO:0051607 ISO
    regulation of mucus secretion GO:0070255 IMP
    necroptotic process GO:0070266 IMP
    pyroptotic inflammatory response GO:0070269 IDA
    pyroptotic inflammatory response GO:0070269 IMP
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IMP
    neutrophil-mediated killing of gram-positive bacterium GO:0070946 IMP
    activation of cysteine-type endopeptidase activity GO:0097202 IMP
    antiviral innate immune response GO:0140374 IDA
    antiviral innate immune response GO:0140374 IMP
    antiviral innate immune response GO:0140374 ISO
    NLRP6 inflammasome complex assembly GO:0140739 IDA
    NLRP6 inflammasome complex assembly GO:0140739 ISO
    positive regulation of interleukin-18-mediated signaling pathway GO:2000494 IDA
    positive regulation of interleukin-18-mediated signaling pathway GO:2000494 IMP
    positive regulation of interleukin-18-mediated signaling pathway GO:2000494 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 IEA
    nuclear membrane GO:0031965 IEA
    membraneless organelle GO:0043228 IDA
    membraneless organelle GO:0043228 ISO
    canonical inflammasome complex GO:0061702 IBA
    canonical inflammasome complex GO:0061702 IDA
    NLRP6 inflammasome complex GO:0140738 IDA
    NLRP6 inflammasome complex GO:0140738 ISO
 Experiment description of studies that identified Nlrp6 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nlrp6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nlrp6 is involved
No pathways found





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