Gene description for SYCP2
Gene name synaptonemal complex protein 2
Gene symbol SYCP2
Other names/aliases SCP2
Species Homo sapiens
 Database cross references - SYCP2
ExoCarta ExoCarta_10388
Entrez Gene 10388
HGNC 11490
MIM 604105
UniProt Q9BX26  
 SYCP2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SYCP2
Molecular Function
    DNA binding GO:0003677 NAS
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    male meiosis GO:0007140 IEA
    fertilization GO:0009566 IEA
    male genitalia morphogenesis GO:0048808 IEA
    synaptonemal complex assembly GO:0007130 NAS
    negative regulation of apoptotic process GO:0043066 IEA
    cell division GO:0051301 IEA
    female meiotic division GO:0007143 IEA
Subcellular Localization
    nucleus GO:0005634 NAS
    synaptonemal complex GO:0000795 NAS
    lateral element GO:0000800 IEA
 Experiment description of studies that identified SYCP2 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SYCP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SYCP2 is involved
PathwayEvidenceSource
Meiotic synapsis TAS Reactome





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