Gene description for Arl1
Gene name ADP-ribosylation factor-like 1
Gene symbol Arl1
Other names/aliases 2310008D22Rik
AU019749
Species Mus musculus
 Database cross references - Arl1
ExoCarta ExoCarta_104303
Vesiclepedia VP_104303
Entrez Gene 104303
UniProt P61211  
 Arl1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Arl1
Molecular Function
    GTPase activity GO:0003924 ISO
    GTPase activity GO:0003924 ISS
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 ISO
    GTP binding GO:0005525 ISS
    enzyme activator activity GO:0008047 ISO
    enzyme activator activity GO:0008047 ISS
    protein domain specific binding GO:0019904 IEA
    protein domain specific binding GO:0019904 ISO
    metal ion binding GO:0046872 IEA
    phospholipase D activator activity GO:1990583 ISO
    phospholipase D activator activity GO:1990583 ISS
Biological Process
    intracellular protein transport GO:0006886 IBA
    Golgi organization GO:0007030 ISO
    Golgi organization GO:0007030 ISS
    toxin metabolic process GO:0009404 ISO
    toxin metabolic process GO:0009404 ISS
    vesicle-mediated transport GO:0016192 IBA
    protein localization to Golgi apparatus GO:0034067 ISO
    protein localization to Golgi apparatus GO:0034067 ISS
    retrograde transport, endosome to Golgi GO:0042147 ISO
    retrograde transport, endosome to Golgi GO:0042147 ISS
    Golgi vesicle transport GO:0048193 ISO
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 ISO
    Golgi apparatus GO:0005794 ISS
    trans-Golgi network GO:0005802 ISO
    trans-Golgi network GO:0005802 ISS
    cytosol GO:0005829 IEA
 Experiment description of studies that identified Arl1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Arl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Atxn1  
Affinity Capture-MS Mus musculus
3 Eed  
Affinity Capture-MS Mus musculus
4 Myd88  
Affinity Capture-MS Mus musculus
5 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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