Gene description for Smek2
Gene name SMEK homolog 2, suppressor of mek1 (Dictyostelium)
Gene symbol Smek2
Other names/aliases AW011752
AW557776
mKIAA1387
Species Mus musculus
 Database cross references - Smek2
ExoCarta ExoCarta_104570
Entrez Gene 104570
UniProt Q922R5  
 Smek2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Smek2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of gluconeogenesis GO:0045722 IDA
    protein dephosphorylation GO:0006470 IMP
    regulation of lipid metabolic process GO:0019216 ISO
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    protein phosphatase 4 complex GO:0030289 IDA
    nucleoplasm GO:0005654 ISO
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified Smek2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Smek2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Smek2 is involved
No pathways found





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