Gene description for Slc39a6
Gene name solute carrier family 39 (metal ion transporter), member 6
Gene symbol Slc39a6
Other names/aliases Ermelin
Species Mus musculus
 Database cross references - Slc39a6
ExoCarta ExoCarta_106957
Vesiclepedia VP_106957
Entrez Gene 106957
UniProt Q8C145  
 Slc39a6 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Slc39a6
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 ISO
    metal ion transmembrane transporter activity GO:0046873 IEA
Biological Process
    metal ion transport GO:0030001 IEA
    zinc II ion transmembrane transport GO:0071577 ISO
    transport GO:0006810 IEA
    ion transport GO:0006811 IEA
    transmembrane transport GO:0055085 IEA
    zinc II ion transport GO:0006829 IEA
    cellular zinc ion homeostasis GO:0006882 ISO
    zinc II ion transmembrane import GO:0071578 ISO
Subcellular Localization
    lamellipodium membrane GO:0031258 ISO
    endoplasmic reticulum GO:0005783 IDA
    integral component of membrane GO:0016021 IEA
    cell surface GO:0009986 ISO
    plasma membrane GO:0005886 ISO
    integral component of plasma membrane GO:0005887 ISO
    membrane GO:0016020 IEA
 Experiment description of studies that identified Slc39a6 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Slc39a6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc39a6 is involved
PathwayEvidenceSource
Zinc influx into cells by the SLC39 gene family IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here