Gene description for Acaca
Gene name acetyl-Coenzyme A carboxylase alpha
Gene symbol Acaca
Other names/aliases A530025K05Rik
Acac
Acc1
Gm738
Species Mus musculus
 Database cross references - Acaca
ExoCarta ExoCarta_107476
Vesiclepedia VP_107476
Entrez Gene 107476
UniProt Q5SWU9  
 Acaca identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Acaca
Molecular Function
    acetyl-CoA carboxylase activity GO:0003989 IBA
    acetyl-CoA carboxylase activity GO:0003989 IDA
    acetyl-CoA carboxylase activity GO:0003989 IGI
    acetyl-CoA carboxylase activity GO:0003989 IMP
    acetyl-CoA carboxylase activity GO:0003989 ISO
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    biotin binding GO:0009374 ISO
    kinase binding GO:0019900 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    tissue homeostasis GO:0001894 IMP
    acetyl-CoA metabolic process GO:0006084 IDA
    lipid metabolic process GO:0006629 IMP
    fatty acid biosynthetic process GO:0006633 IBA
    fatty acid biosynthetic process GO:0006633 IDA
    fatty acid biosynthetic process GO:0006633 ISO
    lipid biosynthetic process GO:0008610 IGI
    lipid biosynthetic process GO:0008610 IMP
    response to organic cyclic compound GO:0014070 ISO
    protein metabolic process GO:0019538 IMP
    protein homotetramerization GO:0051289 IDA
    lipid homeostasis GO:0055088 IMP
    cellular response to prostaglandin E stimulus GO:0071380 IDA
    malonyl-CoA biosynthetic process GO:2001295 IEA
Subcellular Localization
    fibrillar center GO:0001650 IEA
    fibrillar center GO:0001650 ISO
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 IGI
    cytosol GO:0005829 ISO
    actin cytoskeleton GO:0015629 IEA
    actin cytoskeleton GO:0015629 ISO
 Experiment description of studies that identified Acaca in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Acaca
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Trp53  
Phenotypic Enhancement Mus musculus
2 Atxn1  
Affinity Capture-MS Mus musculus
3 Brca1  
Affinity Capture-Western Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Sirt1  
Affinity Capture-Western Mus musculus
6 ABCG1  
Affinity Capture-MS Homo sapiens
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