Gene description for Ltbp4
Gene name latent transforming growth factor beta binding protein 4
Gene symbol Ltbp4
Other names/aliases 2310046A13Rik
Species Mus musculus
 Database cross references - Ltbp4
ExoCarta ExoCarta_108075
Entrez Gene 108075
UniProt Q8K4G1  
 Ltbp4 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Ltbp4
Molecular Function
    calcium ion binding GO:0005509 IEA
    growth factor binding GO:0019838 IEA
    transforming growth factor beta binding GO:0050431 ISO
Biological Process
    regulation of proteolysis GO:0030162 ISO
    hormone secretion GO:0046879 IMP
    transforming growth factor beta receptor signaling pathway GO:0007179 IMP
Subcellular Localization
    extracellular matrix GO:0031012 ISO
    proteinaceous extracellular matrix GO:0005578 ISO
    extracellular exosome GO:0070062 ISO
    extracellular region GO:0005576 IEA
    cell GO:0005623 IMP
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Ltbp4 in exosomes
1
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ltbp4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ltbp4 is involved
PathwayEvidenceSource
Molecules associated with elastic fibres IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here