Gene description for Aida
Gene name axin interactor, dorsalization associated
Gene symbol Aida
Other names/aliases 2610208M17Rik
BC004835
Species Mus musculus
 Database cross references - Aida
ExoCarta ExoCarta_108909
Vesiclepedia VP_108909
Entrez Gene 108909
UniProt Q8C4Q6  
 Aida identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Aida
Molecular Function
    protein binding GO:0005515 IPI
    protein domain specific binding GO:0019904 IPI
    phosphatidylinositol binding GO:0035091 IBA
Biological Process
    dorsal/ventral pattern formation GO:0009953 ISO
    dorsal/ventral pattern formation GO:0009953 ISS
    negative regulation of Wnt signaling pathway GO:0030178 IMP
    negative regulation of protein-containing complex assembly GO:0031333 IMP
    regulation of protein-containing complex assembly GO:0043254 IMP
    negative regulation of JUN kinase activity GO:0043508 IDA
    negative regulation of JUN kinase activity GO:0043508 IMP
    negative regulation of JUN kinase activity GO:0043508 ISO
    negative regulation of JNK cascade GO:0046329 IMP
    negative regulation of JNK cascade GO:0046329 IPI
    negative regulation of JNK cascade GO:0046329 ISO
    determination of ventral identity GO:0048264 IBA
    determination of ventral identity GO:0048264 ISO
    negative regulation of determination of dorsal identity GO:2000016 ISO
Subcellular Localization
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 IBA
 Experiment description of studies that identified Aida in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Aida
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atg16l1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Aida is involved
No pathways found





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