Gene description for Sp110
Gene name Sp110 nuclear body protein
Gene symbol Sp110
Other names/aliases 5031415C07Rik
52kDa
5830484A20Rik
ENSMUSG00000075603
Ifi75
Ipr1
Species Mus musculus
 Database cross references - Sp110
ExoCarta ExoCarta_109032
Entrez Gene 109032
UniProt Q8BVK9  
 Sp110 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Sp110
Molecular Function
    chromatin binding GO:0003682 IBA
    DNA binding GO:0003677 IEA
Biological Process
    chromatin remodeling GO:0006338 IBA
    regulation of transcription, DNA-templated GO:0006355 IBA
    apoptotic process GO:0006915 IEA
    innate immune response GO:0045087 IEA
    positive regulation of apoptotic process GO:0043065 IDA
    immune system process GO:0002376 IEA
    response to bacterium GO:0009617 IDA
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleolus GO:0005730 ISO
 Experiment description of studies that identified Sp110 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Sp110
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sp110 is involved
No pathways found





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