Gene description for Atl3
Gene name atlastin GTPase 3
Gene symbol Atl3
Other names/aliases 4633402C03Rik
5730596K20Rik
AI465397
AW228836
Species Mus musculus
 Database cross references - Atl3
ExoCarta ExoCarta_109168
Vesiclepedia VP_109168
Entrez Gene 109168
UniProt Q91YH5  
 Atl3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Atl3
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IEA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IEA
    identical protein binding GO:0042802 ISO
    identical protein binding GO:0042802 ISS
Biological Process
    endoplasmic reticulum organization GO:0007029 IBA
    endoplasmic reticulum organization GO:0007029 ISO
    endoplasmic reticulum organization GO:0007029 ISS
    Golgi organization GO:0007030 ISO
    Golgi organization GO:0007030 ISS
    protein homooligomerization GO:0051260 IBA
    protein homooligomerization GO:0051260 ISO
    protein homooligomerization GO:0051260 ISS
    cellular response to type II interferon GO:0071346 IEA
    positive regulation of endoplasmic reticulum tubular network organization GO:1903373 ISO
    positive regulation of endoplasmic reticulum tubular network organization GO:1903373 ISS
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum GO:0005783 ISS
    membrane GO:0016020 ISO
    membrane GO:0016020 ISS
    endoplasmic reticulum tubular network GO:0071782 ISO
    endoplasmic reticulum tubular network GO:0071782 ISS
    endoplasmic reticulum tubular network membrane GO:0098826 ISO
    endoplasmic reticulum tubular network membrane GO:0098826 ISS
 Experiment description of studies that identified Atl3 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Atl3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atl3 is involved
No pathways found





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