Gene description for Sri
Gene name sorcin
Gene symbol Sri
Other names/aliases 2210417O06Rik
2900070H08Rik
Sor
Species Mus musculus
 Database cross references - Sri
ExoCarta ExoCarta_109552
Entrez Gene 109552
UniProt Q6P069  
 Sri identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Sri
Molecular Function
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 ISO
    metal ion binding GO:0046872 IEA
    protease binding GO:0002020 ISO
    calcium-dependent cysteine-type endopeptidase activity GO:0004198 IBA
    calcium ion binding GO:0005509 ISO
    repressing transcription factor binding GO:0070491 IPI
Biological Process
    regulation of high voltage-gated calcium channel activity GO:1901841 ISO
    regulation of cardiac muscle cell contraction GO:0086004 ISO
    proteolysis GO:0006508 IBA
    regulation of calcium ion transport GO:0051924 ISO
    negative regulation of heart rate GO:0010459 ISO
    regulation of relaxation of muscle GO:1901077 ISO
    calcium ion transport GO:0006816 IPI
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IMP
    negative regulation of transcription regulatory region DNA binding GO:2000678 IMP
    regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 ISO
    negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 ISO
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IMP
    cytoplasmic sequestering of transcription factor GO:0042994 IMP
Subcellular Localization
    dendritic spine neck GO:0044326 ISO
    smooth endoplasmic reticulum GO:0005790 ISO
    extracellular exosome GO:0070062 ISO
    cytosol GO:0005829 ISO
    axon terminus GO:0043679 ISO
    cell GO:0005623 IMP
    vesicle GO:0031982 IDA
    Z disc GO:0030018 ISO
    T-tubule GO:0030315 ISO
    chromaffin granule membrane GO:0042584 ISO
    sarcoplasmic reticulum GO:0016529 IEA
    axon GO:0030424 ISO
    endoplasmic reticulum membrane GO:0005789 ISO
    mitochondrion GO:0005739 ISO
    membrane GO:0016020 ISO
    plasma membrane GO:0005886 ISO
    intracellular GO:0005622 IDA
    cytoplasm GO:0005737 ISO
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Sri in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Sri
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sri is involved
PathwayEvidenceSource
Stimuli-sensing channels IEA Reactome





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