Gene description for Sri
Gene name sorcin
Gene symbol Sri
Other names/aliases 2210417O06Rik
2900070H08Rik
Sor
Species Mus musculus
 Database cross references - Sri
ExoCarta ExoCarta_109552
Vesiclepedia VP_109552
Entrez Gene 109552
UniProt Q6P069  
 Sri identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Mast cells 17486113    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Sri
Molecular Function
    protease binding GO:0002020 IEA
    protease binding GO:0002020 ISO
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IEA
    calcium ion binding GO:0005509 ISO
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISO
    protein heterodimerization activity GO:0046982 IEA
    protein heterodimerization activity GO:0046982 ISO
    DNA-binding transcription factor binding GO:0140297 IPI
Biological Process
    calcium ion transport GO:0006816 IPI
    negative regulation of heart rate GO:0010459 IEA
    negative regulation of heart rate GO:0010459 ISO
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IMP
    cytoplasmic sequestering of transcription factor GO:0042994 IMP
    positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IMP
    regulation of calcium ion transport GO:0051924 ISO
    negative regulation of cardiac muscle contraction GO:0055118 IMP
    negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 ISO
    regulation of cardiac muscle cell contraction GO:0086004 IEA
    regulation of cardiac muscle cell contraction GO:0086004 ISO
    regulation of relaxation of muscle GO:1901077 IEA
    regulation of relaxation of muscle GO:1901077 ISO
    regulation of high voltage-gated calcium channel activity GO:1901841 ISO
    regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 IEA
    regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 ISO
    negative regulation of transcription regulatory region DNA binding GO:2000678 IMP
Subcellular Localization
    intracellular anatomical structure GO:0005622 IDA
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    endoplasmic reticulum membrane GO:0005789 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 ISO
    Z disc GO:0030018 IDA
    Z disc GO:0030018 ISO
    T-tubule GO:0030315 ISO
    axon GO:0030424 ISO
    vesicle GO:0031982 IDA
    sarcoplasmic reticulum membrane GO:0033017 IEA
    chromaffin granule membrane GO:0042584 IEA
    chromaffin granule membrane GO:0042584 ISO
    axon terminus GO:0043679 ISO
    dendritic spine neck GO:0044326 ISO
    extracellular exosome GO:0070062 IEA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Sri in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Sri
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Psen2  
Affinity Capture-Western Mus musculus
2 Ryr2  
Affinity Capture-Western Mus musculus
3 Anxa7 11750
Co-fractionation Mus musculus
4 Anxa11 11744
Co-fractionation Mus musculus
View the network image/svg+xml



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