ExoCarta: Gene summary

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Gene description for Clps
Gene name	colipase, pancreatic
Gene symbol	Clps
Other names/aliases	2200003J09Rik
Species	Mus musculus
Database cross references - Clps
ExoCarta	ExoCarta_109791
Vesiclepedia	VP_109791
Entrez Gene	109791
UniProt	Q9CQC2
Clps identified in sEVs derived from the following tissue/cell type
Faeces	33431899
Faeces	33431899

Gene ontology annotations for Clps

Molecular Function
	enzyme activator activity	GO:0008047	IEA
	enzyme activator activity	GO:0008047	IMP
	enzyme activator activity	GO:0008047	ISO
	lipase binding	GO:0035473	IEA
Biological Process
	retinoid metabolic process	GO:0001523	IMP
	digestion	GO:0007586	IEA
	response to bacterium	GO:0009617	IEP
	lipid catabolic process	GO:0016042	IEA
	response to food	GO:0032094	IBA
Subcellular Localization
	extracellular region	GO:0005576	IEA

Experiment description of studies that identified Clps in sEVs

Experiment ID

303

MISEV standards
✔ EM	Biophysical techniques
✔ Cd63\|Cd81\|Cd9	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

33431899

Organism

Mus musculus

Experiment description

High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance

Authors

"Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."

Journal name

Nat Commun

Publication year

2021

Sample

Faeces

Sample name

Intestinal epithelial cells - C57BL/6

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation

Flotation density

Molecules identified in the study

Protein
Lipid
miRNA

Methods used in the study

Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC