Gene description for Pgd
Gene name phosphogluconate dehydrogenase
Gene symbol Pgd
Other names/aliases 0610042A05Rik
AU019875
C78335
Species Mus musculus
 Database cross references - Pgd
ExoCarta ExoCarta_110208
Entrez Gene 110208
UniProt Q9DCD0  
 Pgd identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Pgd
Molecular Function
    oxidoreductase activity GO:0016491 IEA
    carboxylic acid binding GO:0031406 ISO
    carbohydrate binding GO:0030246 ISO
    phosphogluconate 2-dehydrogenase activity GO:0008114 IEA
    NADP binding GO:0050661 ISO
    phosphogluconate dehydrogenase (decarboxylating) activity GO:0004616 ISO
Biological Process
    carbohydrate metabolic process GO:0005975 ISO
    D-gluconate metabolic process GO:0019521 ISO
    pentose biosynthetic process GO:0019322 IDA
    oxidation-reduction process GO:0055114 ISO
    pentose-phosphate shunt GO:0006098 ISO
    NADP metabolic process GO:0006739 ISO
    pentose-phosphate shunt, oxidative branch GO:0009051 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Pgd in exosomes
1
Experiment ID 214
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pgd
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pgd is involved
PathwayEvidenceSource
Pentose phosphate pathway (hexose monophosphate shunt) IEA Reactome





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