Gene description for Prps2
Gene name phosphoribosyl pyrophosphate synthetase 2
Gene symbol Prps2
Other names/aliases 2610101M19Rik
AA589463
AI464149
Prps-2
Species Mus musculus
 Database cross references - Prps2
ExoCarta ExoCarta_110639
Vesiclepedia VP_110639
Entrez Gene 110639
UniProt Q9CS42  
 Prps2 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Prps2
Molecular Function
    identical protein binding GO:0042802 ISO
    nucleotide binding GO:0000166 IEA
    magnesium ion binding GO:0000287 ISO
    kinase activity GO:0016301 IEA
    metal ion binding GO:0046872 IEA
    ribose phosphate diphosphokinase activity GO:0004749 ISO
    AMP binding GO:0016208 ISO
    transferase activity GO:0016740 IEA
    ADP binding GO:0043531 ISO
    GDP binding GO:0019003 ISO
    carbohydrate binding GO:0030246 ISO
    ATP binding GO:0005524 ISO
Biological Process
    nucleotide biosynthetic process GO:0009165 ISO
    ribonucleoside monophosphate biosynthetic process GO:0009156 IEA
    ribose phosphate metabolic process GO:0019693 ISO
    5-phosphoribose 1-diphosphate biosynthetic process GO:0006015 ISO
    phosphorylation GO:0016310 IEA
    cellular biosynthetic process GO:0044249 IEA
    AMP biosynthetic process GO:0006167 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    protein complex GO:0043234 ISO
    ribose phosphate diphosphokinase complex GO:0002189 ISO
 Experiment description of studies that identified Prps2 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Prps2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Prps2 is involved
No pathways found





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