Gene description for Slc18a1
Gene name solute carrier family 18 (vesicular monoamine), member 1
Gene symbol Slc18a1
Other names/aliases 4832416I10Rik
Vat1
Vmat1
Species Mus musculus
 Database cross references - Slc18a1
ExoCarta ExoCarta_110877
Entrez Gene 110877
UniProt Q8R090  
 Slc18a1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Slc18a1
Molecular Function
    serotonin transmembrane transporter activity GO:0015222 ISO
    drug transmembrane transporter activity GO:0015238 IEA
    enzyme binding GO:0019899 ISO
Biological Process
    positive regulation of dopamine secretion GO:0033603 ISO
    transmembrane transport GO:0055085 IEA
    drug transport GO:0015893 IEA
    negative regulation of serotonin uptake GO:0051612 ISO
    transport GO:0006810 IEA
    serotonin uptake GO:0051610 ISO
    ammonium transmembrane transport GO:0072488 ISO
    neurotransmitter transport GO:0006836 IEA
    organic cation transport GO:0015695 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 IEA
    integral component of membrane GO:0016021 IEA
    cytoplasmic vesicle GO:0031410 IEA
 Experiment description of studies that identified Slc18a1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Slc18a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc18a1 is involved
PathwayEvidenceSource
Na+/Cl- dependent neurotransmitter transporters IEA Reactome





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