Gene description for PADI2
Gene name peptidyl arginine deiminase, type II
Gene symbol PADI2
Other names/aliases PAD-H19
PAD2
PDI2
Species Homo sapiens
 Database cross references - PADI2
ExoCarta ExoCarta_11240
Vesiclepedia VP_11240
Entrez Gene 11240
HGNC 18341
MIM 607935
UniProt Q9Y2J8  
 PADI2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for PADI2
Molecular Function
    calcium ion binding GO:0005509 IEA
    estrogen receptor binding GO:0030331 IPI
    protein-arginine deiminase activity GO:0004668 IDA
Biological Process
    regulation of chromatin disassembly GO:0010848 IDA
    protein citrullination GO:0018101 IDA
    chromatin-mediated maintenance of transcription GO:0048096 IMP
    histone H3-R26 citrullination GO:0036413 IDA
    negative regulation of lymphocyte chemotaxis GO:1901624 IDA
    negative regulation of chemokine-mediated signaling pathway GO:0070100 IDA
    intracellular estrogen receptor signaling pathway GO:0030520 IMP
    substantia nigra development GO:0021762 IEP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    extracellular exosome GO:0070062 IDA
    transcriptionally active chromatin GO:0035327 IDA
 Experiment description of studies that identified PADI2 in exosomes
1
Experiment ID 217
MISEV standards
EM
EV Biophysical techniques
TSG101|CD81|CD9|CD63
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 63
MISEV standards
EV Biophysical techniques
AQP2
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PADI2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PADI2 is involved
No pathways found





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