Gene description for SLC6A14
Gene name solute carrier family 6 (amino acid transporter), member 14
Gene symbol SLC6A14
Other names/aliases BMIQ11
Species Homo sapiens
 Database cross references - SLC6A14
ExoCarta ExoCarta_11254
Vesiclepedia VP_11254
Entrez Gene 11254
HGNC 11047
MIM 300444
UniProt Q9UN76  
 SLC6A14 identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
Tracheobronchial cells 19190083    
 Gene ontology annotations for SLC6A14
Molecular Function
    beta-alanine transmembrane transporter activity GO:0001761 IBA
    beta-alanine transmembrane transporter activity GO:0001761 IDA
    amino acid transmembrane transporter activity GO:0015171 TAS
    aromatic amino acid transmembrane transporter activity GO:0015173 IDA
    neutral, basic amino acid:sodium:chloride symporter activity GO:0015374 IBA
    neutral, basic amino acid:sodium:chloride symporter activity GO:0015374 IDA
    branched-chain amino acid:sodium symporter activity GO:0015657 IBA
    branched-chain amino acid:sodium symporter activity GO:0015657 IDA
    alanine transmembrane transporter activity GO:0022858 IBA
    alanine transmembrane transporter activity GO:0022858 IDA
    (R)-carnitine transmembrane transporter activity GO:1901235 IBA
    (R)-carnitine transmembrane transporter activity GO:1901235 IDA
    (R)-carnitine transmembrane transporter activity GO:1901235 ISS
Biological Process
    beta-alanine transport GO:0001762 IBA
    beta-alanine transport GO:0001762 IDA
    amino acid transmembrane transport GO:0003333 TAS
    chloride transport GO:0006821 IEA
    amino acid transport GO:0006865 TAS
    response to toxic substance GO:0009636 IDA
    aromatic amino acid transport GO:0015801 IEA
    branched-chain amino acid transport GO:0015803 IEA
    alanine transport GO:0032328 IDA
    sodium ion transmembrane transport GO:0035725 IBA
    amino acid import across plasma membrane GO:0089718 IDA
    (R)-carnitine transmembrane transport GO:1902270 IBA
    (R)-carnitine transmembrane transport GO:1902270 IDA
    (R)-carnitine transmembrane transport GO:1902270 ISS
    glycine import across plasma membrane GO:1903804 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 TAS
    apical plasma membrane GO:0016324 ISS
    vesicle GO:0031982 HDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLC6A14 in sEVs
1
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 34
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
TSG101|CD63|MHCI|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19190083    
Organism Homo sapiens
Experiment description Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
Authors "Kesimer M, Scull M, Brighton B, Demaria G, Burns K, O'Neal W, Pickles RJ, Sheehan JK"
Journal name FASEB
Publication year 2009
Sample Tracheobronchial cells
Sample name Tracheobronchial epithelial cells
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.16 -1.18 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
FACS
 Protein-protein interactions for SLC6A14
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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