Gene description for SLC6A14
Gene name solute carrier family 6 (amino acid transporter), member 14
Gene symbol SLC6A14
Other names/aliases BMIQ11
Species Homo sapiens
 Database cross references - SLC6A14
ExoCarta ExoCarta_11254
Entrez Gene 11254
HGNC 11047
MIM 300444
UniProt Q9UN76  
 SLC6A14 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
Tracheobronchial cells 19190083    
 Gene ontology annotations for SLC6A14
Molecular Function
    neurotransmitter:sodium symporter activity GO:0005328 IEA
    amino acid transmembrane transporter activity GO:0015171 TAS
Biological Process
    transmembrane transport GO:0055085 TAS
    cellular amino acid metabolic process GO:0006520 TAS
    neurotransmitter transport GO:0006836 IEA
    transport GO:0006810 TAS
    amino acid transport GO:0006865 TAS
    ion transport GO:0006811 TAS
    amino acid transmembrane transport GO:0003333 TAS
    response to toxic substance GO:0009636 IDA
Subcellular Localization
    vesicle GO:0031982 IDA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 TAS
    brush border membrane GO:0031526 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SLC6A14 in exosomes
1
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 34
ISEV standards
✔
EM|IEM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD63|MHCI|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19190083    
Organism Homo sapiens
Experiment description Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
Authors Kesimer M, Scull M, Brighton B, Demaria G, Burns K, O'Neal W, Pickles RJ, Sheehan JK
Journal name FASEB
Publication year 2009
Sample Tracheobronchial cells
Sample name Tracheobronchial epithelial cells
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.16 -1.18 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
FACS
 Protein-protein interactions for SLC6A14
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC6A14 is involved
PathwayEvidenceSource
Amino acid transport across the plasma membrane TAS Reactome
Na+/Cl- dependent neurotransmitter transporters TAS Reactome





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