Gene description for Abca1
Gene name	ATP-binding cassette, sub-family A (ABC1), member 1
Gene symbol	Abca1
Other names/aliases	ABC-1 Abc1
Species	Mus musculus
Database cross references - Abca1
ExoCarta	ExoCarta_11303
Vesiclepedia	VP_11303
Entrez Gene	11303
UniProt	P41233
Abca1 identified in sEVs derived from the following tissue/cell type
Melanoma cells	34957415
Melanoma cells	34957415
Melanoma cells	34957415

Gene ontology annotations for Abca1

Molecular Function     signaling receptor binding GO:0005102 IEA     signaling receptor binding GO:0005102 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ATP binding GO:0005524 ISO     phospholipid transporter activity GO:0005548 IDA     phospholipid transporter activity GO:0005548 IMP     phospholipid transporter activity GO:0005548 ISO     high-density lipoprotein particle binding GO:0008035 IEA     high-density lipoprotein particle binding GO:0008035 ISO     protein transmembrane transporter activity GO:0008320 IMP     ATP hydrolysis activity GO:0016887 IEA     syntaxin binding GO:0019905 IEA     syntaxin binding GO:0019905 ISO     phosphatidylcholine binding GO:0031210 IEA     phosphatidylcholine binding GO:0031210 ISO     small GTPase binding GO:0031267 IEA     small GTPase binding GO:0031267 ISO     apolipoprotein binding GO:0034185 ISO     apolipoprotein A-I binding GO:0034186 IEA     apolipoprotein A-I binding GO:0034186 ISO     apolipoprotein A-I receptor activity GO:0034188 IEA     apolipoprotein A-I receptor activity GO:0034188 ISO     ATPase-coupled transmembrane transporter activity GO:0042626 IBA     ATPase-coupled transmembrane transporter activity GO:0042626 ISO     sphingolipid floppase activity GO:0046623 IEA     sphingolipid floppase activity GO:0046623 ISO     ATPase binding GO:0051117 IEA     ATPase binding GO:0051117 ISO     phosphatidylcholine floppase activity GO:0090554 IBA     phosphatidylcholine floppase activity GO:0090554 ISO     phosphatidylcholine floppase activity GO:0090554 ISS     phosphatidylserine floppase activity GO:0090556 IBA     phosphatidylserine floppase activity GO:0090556 IEA     phosphatidylserine floppase activity GO:0090556 ISO     cholesterol transfer activity GO:0120020 IDA     cholesterol transfer activity GO:0120020 IMP     cholesterol transfer activity GO:0120020 ISO     floppase activity GO:0140328 ISO     floppase activity GO:0140328 ISS     ABC-type transporter activity GO:0140359 IEA Biological Process     peptide secretion GO:0002790 IMP     protein lipidation GO:0006497 IMP     phagocytosis, engulfment GO:0006911 IMP     lysosome organization GO:0007040 IEA     lysosome organization GO:0007040 ISO     G protein-coupled receptor signaling pathway GO:0007186 ISO     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IEA     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 ISO     cholesterol metabolic process GO:0008203 IDA     cholesterol metabolic process GO:0008203 ISO     protein secretion GO:0009306 IMP     protein secretion GO:0009306 ISO     positive regulation of cholesterol efflux GO:0010875 IMP     phospholipid transport GO:0015914 ISO     endosomal transport GO:0016197 IEA     endosomal transport GO:0016197 ISO     signal release GO:0023061 IMP     signal release GO:0023061 ISO     cholesterol transport GO:0030301 ISO     intracellular cholesterol transport GO:0032367 IEA     intracellular cholesterol transport GO:0032367 ISO     regulation of Cdc42 protein signal transduction GO:0032489 IEA     regulation of Cdc42 protein signal transduction GO:0032489 ISO     cholesterol efflux GO:0033344 IDA     cholesterol efflux GO:0033344 IMP     cholesterol efflux GO:0033344 IMP     cholesterol efflux GO:0033344 ISO     response to vitamin B3 GO:0033552 IEA     phospholipid efflux GO:0033700 IBA     phospholipid efflux GO:0033700 IDA     phospholipid efflux GO:0033700 IMP     phospholipid efflux GO:0033700 ISO     high-density lipoprotein particle assembly GO:0034380 IEA     high-density lipoprotein particle assembly GO:0034380 ISO     response to laminar fluid shear stress GO:0034616 IEA     response to laminar fluid shear stress GO:0034616 ISO     apolipoprotein A-I-mediated signaling pathway GO:0038027 IEA     lipoprotein metabolic process GO:0042157 IMP     lipoprotein biosynthetic process GO:0042158 IMP     lipoprotein biosynthetic process GO:0042158 ISO     cholesterol homeostasis GO:0042632 IEA     cholesterol homeostasis GO:0042632 ISO     reverse cholesterol transport GO:0043691 IMP     reverse cholesterol transport GO:0043691 ISO     phospholipid translocation GO:0045332 IMP     phospholipid translocation GO:0045332 ISO     establishment of localization in cell GO:0051649 IMP     phospholipid homeostasis GO:0055091 IEA     phospholipid homeostasis GO:0055091 ISO     platelet dense granule organization GO:0060155 IEA     platelet dense granule organization GO:0060155 ISO     cellular response to lipopolysaccharide GO:0071222 IDA     cellular response to retinoic acid GO:0071300 IDA     cellular response to cytokine stimulus GO:0071345 IEA     cellular response to cholesterol GO:0071397 IEA     cellular response to high density lipoprotein particle stimulus GO:0071403 IMP     cellular response to xenobiotic stimulus GO:0071466 IEA     protein transmembrane transport GO:0071806 IMP     positive regulation of high-density lipoprotein particle assembly GO:0090108 IMP     sphingolipid translocation GO:0099039 IEA     export across plasma membrane GO:0140115 IMP Subcellular Localization     endosome GO:0005768 ISO     endosome GO:0005768 ISS     Golgi apparatus GO:0005794 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     external side of plasma membrane GO:0009897 IDA     cell surface GO:0009986 ISO     basolateral plasma membrane GO:0016323 IEA     basolateral plasma membrane GO:0016323 ISO     endocytic vesicle GO:0030139 ISO     intracellular membrane-bounded organelle GO:0043231 IBA     intracellular membrane-bounded organelle GO:0043231 IDA     membrane raft GO:0045121 IEA     membrane raft GO:0045121 ISO     phagocytic vesicle GO:0045335 IEA     phagocytic vesicle GO:0045335 ISO     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     intracellular vesicle GO:0097708 ISO