Gene description for Prdx5
Gene name peroxiredoxin 5
Gene symbol Prdx5
Other names/aliases Aoeb166
Species Rattus norvegicus
 Database cross references - Prdx5
ExoCarta ExoCarta_113898
Vesiclepedia VP_113898
Entrez Gene 113898
UniProt Q9R063  
 Prdx5 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Urine 20535238    
 Gene ontology annotations for Prdx5
Molecular Function
    RNA polymerase III transcription regulatory region sequence-specific DNA binding GO:0001016 IEA
    RNA polymerase III transcription regulatory region sequence-specific DNA binding GO:0001016 ISO
    peroxidase activity GO:0004601 ISO
    signaling receptor binding GO:0005102 ISO
    thioredoxin peroxidase activity GO:0008379 IBA
    thioredoxin peroxidase activity GO:0008379 IEA
    thioredoxin peroxidase activity GO:0008379 ISO
    antioxidant activity GO:0016209 ISO
    identical protein binding GO:0042802 ISO
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 IEA
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 ISO
    peroxynitrite reductase activity GO:0072541 ISO
    thioredoxin-dependent peroxiredoxin activity GO:0140824 ISO
Biological Process
    response to oxidative stress GO:0006979 ISO
    negative regulation of transcription by RNA polymerase III GO:0016480 IEA
    negative regulation of transcription by RNA polymerase III GO:0016480 ISO
    positive regulation of collagen biosynthetic process GO:0032967 ISO
    cellular response to oxidative stress GO:0034599 IBA
    cellular response to oxidative stress GO:0034599 IEA
    cellular response to reactive oxygen species GO:0034614 IEA
    cellular response to reactive oxygen species GO:0034614 ISO
    hydrogen peroxide catabolic process GO:0042744 IBA
    hydrogen peroxide catabolic process GO:0042744 ISO
    negative regulation of apoptotic process GO:0043066 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    cell redox homeostasis GO:0045454 IBA
    negative regulation of oxidoreductase activity GO:0051354 ISO
    regulation of apoptosis involved in tissue homeostasis GO:0060785 ISO
    NADPH oxidation GO:0070995 ISO
    cellular oxidant detoxification GO:0098869 IEA
    reactive nitrogen species metabolic process GO:2001057 ISO
Subcellular Localization
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
    peroxisome GO:0005777 IBA
    peroxisome GO:0005777 IDA
    peroxisome GO:0005777 IEA
    peroxisome GO:0005777 ISO
    peroxisomal matrix GO:0005782 IEA
    peroxisomal matrix GO:0005782 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytoplasmic vesicle GO:0031410 IEA
    cytoplasmic vesicle GO:0031410 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Prdx5 in exosomes
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 192
MISEV standards
CEM
Biophysical techniques
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Prdx5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Gja1  
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml



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