Gene description for Gmfg
Gene name glia maturation factor, gamma
Gene symbol Gmfg
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Gmfg
ExoCarta ExoCarta_113940
Vesiclepedia VP_113940
Entrez Gene 113940
UniProt Q80T18  
 Gmfg identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Gmfg
Molecular Function
    actin binding GO:0003779 IEA
    growth factor activity GO:0008083 IEA
    kinase regulator activity GO:0019207 NAS
    Arp2/3 complex binding GO:0071933 IBA
    Arp2/3 complex binding GO:0071933 IEA
Biological Process
    signal transduction GO:0007165 IEA
    negative regulation of Arp2/3 complex-mediated actin nucleation GO:0034316 IBA
    negative regulation of Arp2/3 complex-mediated actin nucleation GO:0034316 IEA
    negative regulation of Arp2/3 complex-mediated actin nucleation GO:0034316 ISO
    actin filament debranching GO:0071846 IBA
    actin filament debranching GO:0071846 IEA
    actin filament debranching GO:0071846 ISO
Subcellular Localization
    cortical actin cytoskeleton GO:0030864 IBA
 Experiment description of studies that identified Gmfg in sEVs
1
Experiment ID 96
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Gmfg
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gmfg is involved
PathwayEvidenceSource
Immune System IEA Reactome
Innate Immune System IEA Reactome
Neutrophil degranulation IEA Reactome





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