Gene description for Vegfc
Gene name vascular endothelial growth factor C
Gene symbol Vegfc
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Vegfc
ExoCarta ExoCarta_114111
Vesiclepedia VP_114111
Entrez Gene 114111
UniProt O35757  
 Vegfc identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Vegfc
Molecular Function
    growth factor activity GO:0008083 IBA
    growth factor activity GO:0008083 IEA
    growth factor activity GO:0008083 TAS
    chemoattractant activity GO:0042056 IBA
    chemoattractant activity GO:0042056 ISO
    vascular endothelial growth factor receptor 3 binding GO:0043185 IBA
    vascular endothelial growth factor receptor 3 binding GO:0043185 IMP
    vascular endothelial growth factor receptor 3 binding GO:0043185 ISO
Biological Process
    angiogenesis GO:0001525 IMP
    response to hypoxia GO:0001666 IBA
    sprouting angiogenesis GO:0002040 IBA
    positive regulation of neuroblast proliferation GO:0002052 IDA
    signal transduction GO:0007165 IEA
    cell population proliferation GO:0008283 ISO
    positive regulation of cell population proliferation GO:0008284 IDA
    positive regulation of cell population proliferation GO:0008284 ISO
    response to xenobiotic stimulus GO:0009410 IEP
    animal organ morphogenesis GO:0009887 ISO
    glial cell proliferation GO:0014009 ISO
    morphogenesis of embryonic epithelium GO:0016331 ISO
    positive regulation of cell migration GO:0030335 ISO
    regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 IMP
    positive regulation of protein autophosphorylation GO:0031954 IMP
    vascular endothelial growth factor signaling pathway GO:0038084 IBA
    positive regulation of blood vessel endothelial cell migration GO:0043536 IMP
    negative regulation of osteoblast differentiation GO:0045668 ISO
    regulation of angiogenesis GO:0045765 TAS
    positive regulation of angiogenesis GO:0045766 ISO
    negative regulation of blood pressure GO:0045776 IMP
    positive regulation of protein kinase activity GO:0045860 ISO
    vascular endothelial growth factor receptor signaling pathway GO:0048010 IBA
    vascular endothelial growth factor receptor signaling pathway GO:0048010 ISO
    vascular endothelial growth factor receptor signaling pathway GO:0048010 ISO
    vascular endothelial growth factor receptor signaling pathway GO:0048010 ISS
    positive regulation of epithelial cell proliferation GO:0050679 IMP
    positive regulation of protein secretion GO:0050714 IMP
    positive chemotaxis GO:0050918 IEA
    induction of positive chemotaxis GO:0050930 IBA
    induction of positive chemotaxis GO:0050930 ISO
    positive regulation of cell division GO:0051781 IEA
    positive regulation of glial cell proliferation GO:0060252 ISO
    positive regulation of mast cell chemotaxis GO:0060754 IBA
    positive regulation of mast cell chemotaxis GO:0060754 ISO
    positive regulation of lymphangiogenesis GO:1901492 ISO
    positive regulation of lymphangiogenesis GO:1901492 ISO
    positive regulation of mesenchymal stem cell proliferation GO:1902462 ISO
    cellular response to leukemia inhibitory factor GO:1990830 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    membrane GO:0016020 IEA
 Experiment description of studies that identified Vegfc in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method RT-PCR
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method RT-PCR
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Vegfc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here