Gene description for Vegfc
Gene name vascular endothelial growth factor C
Gene symbol Vegfc
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Vegfc
ExoCarta ExoCarta_114111
Entrez Gene 114111
UniProt O35757  
 Vegfc identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Vegfc
Molecular Function
    vascular endothelial growth factor receptor 3 binding GO:0043185 ISO
    chemoattractant activity GO:0042056 ISO
    growth factor activity GO:0008083 TAS
Biological Process
    positive regulation of cell division GO:0051781 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    vascular endothelial growth factor receptor signaling pathway GO:0048010 ISO
    organ morphogenesis GO:0009887 ISO
    positive regulation of cell-matrix adhesion GO:0001954 ISO
    positive regulation of mast cell chemotaxis GO:0060754 ISO
    positive regulation of protein autophosphorylation GO:0031954 IMP
    positive regulation of blood vessel endothelial cell migration GO:0043536 IMP
    positive regulation of epithelial cell proliferation GO:0050679 IMP
    response to drug GO:0042493 IEP
    positive regulation of protein secretion GO:0050714 IMP
    positive chemotaxis GO:0050918 ISO
    regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 IMP
    positive regulation of cell proliferation GO:0008284 ISO
    positive regulation of angiogenesis GO:0045766 ISO
    morphogenesis of embryonic epithelium GO:0016331 ISO
    negative regulation of blood pressure GO:0045776 IMP
    positive regulation of lymphangiogenesis GO:1901492 ISO
    angiogenesis GO:0001525 IMP
    positive regulation of neuroblast proliferation GO:0002052 IDA
    induction of positive chemotaxis GO:0050930 ISO
    regulation of angiogenesis GO:0045765 TAS
    negative regulation of cell proliferation GO:0008285 ISO
Subcellular Localization
    membrane GO:0016020 IEA
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Vegfc in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method RT-PCR
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method RT-PCR
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Vegfc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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