Gene description for Aco1
Gene name aconitase 1
Gene symbol Aco1
Other names/aliases Aco-1
Irebp
Irp1
Species Mus musculus
 Database cross references - Aco1
ExoCarta ExoCarta_11428
Vesiclepedia VP_11428
Entrez Gene 11428
UniProt P28271  
 Aco1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Aco1
Molecular Function
    iron-responsive element binding GO:0030350 ISO
    lyase activity GO:0016829 IEA
    metal ion binding GO:0046872 IEA
    aconitate hydratase activity GO:0003994 ISO
    4 iron, 4 sulfur cluster binding GO:0051539 ISO
    RNA binding GO:0003723 ISO
    mRNA 5'-UTR binding GO:0048027 ISO
    iron-sulfur cluster binding GO:0051536 ISO
Biological Process
    intestinal absorption GO:0050892 IGI
    response to iron(II) ion GO:0010040 ISO
    metabolic process GO:0008152 IEA
    citrate metabolic process GO:0006101 ISO
    regulation of translation GO:0006417 IMP
    cellular iron ion homeostasis GO:0006879 ISO
    post-embryonic development GO:0009791 IGI
    tricarboxylic acid cycle GO:0006099 IEA
    regulation of gene expression GO:0010468 IGI
Subcellular Localization
    mitochondrion GO:0005739 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    extracellular exosome GO:0070062 ISO
    cytosol GO:0005829 ISO
    cytoplasm GO:0005737 ISO
    cell GO:0005623 IGI
    Golgi apparatus GO:0005794 ISO
    endoplasmic reticulum GO:0005783 ISO
 Experiment description of studies that identified Aco1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Aco1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aco1 is involved
No pathways found





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