Gene description for Itga6
Gene name integrin, alpha 6
Gene symbol Itga6
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Itga6
ExoCarta ExoCarta_114517
Entrez Gene 114517
 Itga6 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Itga6
Molecular Function
    integrin binding GO:0005178 ISO
    laminin binding GO:0043236 IPI
    protein complex binding GO:0032403 IDA
Biological Process
    cell-substrate adhesion GO:0031589 ISO
    brown fat cell differentiation GO:0050873 ISO
    cell adhesion GO:0007155 IEA
    ectodermal cell differentiation GO:0010668 ISO
    integrin-mediated signaling pathway GO:0007229 IEA
    amelogenesis GO:0097186 ISO
    cell adhesion mediated by integrin GO:0033627 ISO
    positive regulation of cell-cell adhesion GO:0022409 ISO
    odontogenesis of dentin-containing tooth GO:0042475 ISO
    nail development GO:0035878 ISO
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    cell-matrix adhesion GO:0007160 ISO
    positive regulation of cell-substrate adhesion GO:0010811 IMP
    single organismal cell-cell adhesion GO:0016337 IMP
    renal system development GO:0072001 ISO
    leukocyte migration GO:0050900 ISO
    cellular response to extracellular stimulus GO:0031668 ISO
    positive regulation of apoptotic process GO:0043065 ISO
    positive regulation of phosphorylation GO:0042327 ISO
    filopodium assembly GO:0046847 ISO
    skin development GO:0043588 ISO
    digestive tract development GO:0048565 ISO
    cellular response to organic cyclic compound GO:0071407 IEP
Subcellular Localization
    basal part of cell GO:0045178 ISO
    integrin alpha6-beta4 complex GO:0034676 IDA
    integrin complex GO:0008305 ISO
    hemidesmosome GO:0030056 ISO
    external side of plasma membrane GO:0009897 ISO
    basolateral plasma membrane GO:0016323 ISO
    cell surface GO:0009986 ISO
    cell-cell adherens junction GO:0005913 IDA
    basal plasma membrane GO:0009925 ISO
    focal adhesion GO:0005925 ISO
    basement membrane GO:0005604 ISO
    filopodium GO:0030175 IDA
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Itga6 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Itga6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Itga6 is involved
No pathways found





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